Version 5.4
Bos taurus Gene: HBEGF
Summary
InnateDB Gene IDBG-646038.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HBEGF
Gene Name proheparin-binding EGF-like growth factor precursor
Synonyms DTR; HB-EGF
Species Bos taurus
Ensembl Gene ENSBTAG00000021766
Encoded Proteins
IDBP-698808
proheparin-binding EGF-like growth factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113070:
Gene Information
Type Protein coding
Genomic Location Chromosome 7:53216665-53227848
Strand Reverse strand
Band
Transcripts
ENSBTAT00000029015 ENSBTAP00000029015
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005154 epidermal growth factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0008201 heparin binding
Biological Process
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008016 regulation of heart contraction
GO:0016477 cell migration
GO:0030335 positive regulation of cell migration
GO:0035313 wound healing, spreading of epidermal cells
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051549 positive regulation of keratinocyte migration
GO:0051897 positive regulation of protein kinase B signaling
GO:0090303 positive regulation of wound healing
Cellular Component
GO:0005615 extracellular space
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000113070
View Gene Order
ENSMUSG00000024486
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_121096
EGFR Transactivation by Gastrin pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_116005
SHC1 events in ERBB4 signaling pathway
REACT_116022
Nuclear signaling by ERBB4 pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115854
GRB2 events in ERBB2 signaling pathway
REACT_115993
SHC1 events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
REACT_239142
Innate Immune System pathway
REACT_198574
Nuclear signaling by ERBB4 pathway
REACT_188199
Signaling by the B Cell Receptor (BCR) pathway
REACT_188191
Signaling by ERBB2 pathway
REACT_205300
PI3K/AKT activation pathway
REACT_189085
Disease pathway
REACT_254215
Signaling by GPCR pathway
REACT_198350
EGFR Transactivation by Gastrin pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_188579
Signaling by ERBB4 pathway
REACT_188578
Signaling by SCF-KIT pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_188574
SHC1 events in ERBB2 signaling pathway
REACT_226341
PIP3 activates AKT signaling pathway
REACT_230745
Immune System pathway
REACT_230639
Downstream signal transduction pathway
REACT_231729
Downstream signaling of activated FGFR pathway
REACT_196588
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_188580
SHC1 events in ERBB4 signaling pathway
REACT_203296
PI3K events in ERBB4 signaling pathway
REACT_223993
PI-3K cascade pathway
REACT_242976
Signaling by EGFR pathway
REACT_213364
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_226735
PI3K/AKT Signaling in Cancer pathway
REACT_248921
Signalling by NGF pathway
REACT_229531
Adaptive Immune System pathway
REACT_263353
Signaling by PDGF pathway
REACT_206286
GAB1 signalosome pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_215348
PI3K events in ERBB2 signaling pathway
REACT_188257
Signal Transduction pathway
REACT_188528
GRB2 events in ERBB2 signaling pathway
REACT_242456
Signaling by FGFR pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_209507
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_188188
DAP12 interactions pathway
REACT_188185
DAP12 signaling pathway
KEGG
hsa04912
GnRH signaling pathway pathway
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa04012
ErbB signaling pathway pathway
mmu04012
ErbB signaling pathway pathway
mmu04912
GnRH signaling pathway pathway
INOH
INOH website
GPCR signaling pathway
INOH website
GPCR signaling pathway
PID NCI
lysophospholipid_pathway
LPA receptor mediated events
erbb4_pathway
ErbB4 signaling events
erbb_network_pathway
ErbB receptor signaling network
er_nongenomic_pathway
Plasma membrane estrogen receptor signaling
Cross-References
SwissProt
TrEMBL E1BIN8
UniProt Splice Variant
Entrez Gene 522921
UniGene Bt.14152
RefSeq NM_001144090
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02020430
GenPept
RNA Seq Atlas 522921

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca