Version 5.4
Homo sapiens Gene: HBEGF
Summary
InnateDB Gene IDBG-48445.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HBEGF
Gene Name heparin-binding EGF-like growth factor
Synonyms DTR; DTS; DTSF; HEGFL
Species Homo sapiens
Ensembl Gene ENSG00000113070
Encoded Proteins
IDBP-48447
heparin-binding EGF-like growth factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 5:140332843-140346631
Strand Reverse strand
Band q31.3
Transcripts
ENST00000230990 ENSP00000230990
ENST00000482211
ENST00000498452
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 13 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005154 epidermal growth factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0008201 heparin binding
Biological Process
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007517 muscle organ development
GO:0008016 regulation of heart contraction
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0016477 cell migration
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0035313 wound healing, spreading of epidermal cells
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0045087 innate immune response
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051545 negative regulation of elastin biosynthetic process
GO:0051549 positive regulation of keratinocyte migration
GO:0051897 positive regulation of protein kinase B signaling
GO:0090303 positive regulation of wound healing
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024486
View Gene Order
ENSBTAG00000021766
Not yet available
Pathways
NETPATH
REACTOME
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_121096
EGFR Transactivation by Gastrin pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_116005
SHC1 events in ERBB4 signaling pathway
REACT_116022
Nuclear signaling by ERBB4 pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115854
GRB2 events in ERBB2 signaling pathway
REACT_115993
SHC1 events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
KEGG
hsa04912
GnRH signaling pathway pathway
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa04012
ErbB signaling pathway pathway
INOH
INOH website
GPCR signaling pathway
PID NCI
lysophospholipid_pathway
LPA receptor mediated events
erbb4_pathway
ErbB4 signaling events
erbb_network_pathway
ErbB receptor signaling network
er_nongenomic_pathway
Plasma membrane estrogen receptor signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.592942 Hs.799
RefSeq NM_001945
HUGO
OMIM
CCDS CCDS4223
HPRD 00526
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca