InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DIAPH1

Summary

InnateDB Gene

IDBG-646110.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DIAPH1

Gene Name

FCH and double SH3 domains protein 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000030499

Encoded Proteins

IDBP-698891

diaphanous homolog 1 (Drosophila)

IDBP-698893

diaphanous homolog 1 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131504:
This gene is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Actin polymerization involves proteins known to interact with diaphanous protein in Drosophila and mouse. It has therefore been speculated that this gene may have a role in the regulation of actin polymerization in hair cells of the inner ear. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:54285455-54437207

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000023082	ENSBTAP00000023082
ENSBTAT00000021194	ENSBTAP00000021194

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003779	actin binding
GO:0005488	binding
GO:0005515	protein binding
GO:0005522	profilin binding
GO:0017048	Rho GTPase binding
GO:0044325	ion channel binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0007015	actin filament organization
GO:0008360	regulation of cell shape
GO:0016043	cellular component organization
GO:0030036	actin cytoskeleton organization
GO:0030041	actin filament polymerization
GO:0032886	regulation of microtubule-based process
GO:0035372	protein localization to microtubule
GO:0051279	regulation of release of sequestered calcium ion into cytosol
GO:0071420	cellular response to histamine