InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Diap1

Summary

InnateDB Gene

IDBG-140703.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Diap1

Gene Name

diaphanous homolog 1 (Drosophila)

Synonyms

D18Wsu154e; Dia1; Diaph1; Drf1; mKIAA4062; p140mDia

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024456

Encoded Proteins

IDBP-140705

diaphanous homolog 1 (Drosophila)

IDBP-140707

diaphanous homolog 1 (Drosophila)

IDBP-249190

diaphanous homolog 1 (Drosophila)

IDBP-249192

diaphanous homolog 1 (Drosophila)

IDBP-249196

diaphanous homolog 1 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131504:
This gene is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Actin polymerization involves proteins known to interact with diaphanous protein in Drosophila and mouse. It has therefore been speculated that this gene may have a role in the regulation of actin polymerization in hair cells of the inner ear. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:37843601-37935476

Strand

Reverse strand

Band

Transcripts

ENSMUST00000025337	ENSMUSP00000025337
ENSMUST00000080033	ENSMUSP00000078942
ENSMUST00000115634	ENSMUSP00000111297
ENSMUST00000115631	ENSMUSP00000111294
ENSMUST00000115629	ENSMUSP00000111292
ENSMUST00000127346
ENSMUST00000124822
ENSMUST00000129688

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	32 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005488	binding
GO:0005515	protein binding
GO:0005522	profilin binding
GO:0017048	Rho GTPase binding
GO:0042802	identical protein binding
GO:0044325	ion channel binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0007605	sensory perception of sound
GO:0008360	regulation of cell shape
GO:0016043	cellular component organization
GO:0030036	actin cytoskeleton organization
GO:0030041	actin filament polymerization
GO:0030335	positive regulation of cell migration
GO:0031175	neuron projection development
GO:0032886	regulation of microtubule-based process
GO:0035372	protein localization to microtubule
GO:0051279	regulation of release of sequestered calcium ion into cytosol
GO:0071420	cellular response to histamine

Cellular Component

GO:0005737	cytoplasm
GO:0032587	ruffle membrane
GO:0043005	neuron projection
GO:0072686	mitotic spindle

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000131504

View Gene Order

ENSBTAG00000030499

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04810

Regulation of actin cytoskeleton pathway

mmu04510

Focal adhesion pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_11

TCR pathway

REACTOME

KEGG

hsa04810

Regulation of actin cytoskeleton pathway

hsa04510

Focal adhesion pathway

hsa05131

Shigellosis pathway

INOH

PID NCI

ilk_pathway

Integrin-linked kinase signaling

rhoa_pathway

RhoA signaling pathway

ecadherin_stabilization_pathway

Stabilization and expansion of the E-cadherin adherens junction

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.195916 Mm.401799

RefSeq

NM_007858 XM_006525589 XM_006525590

OMIM

CCDS

CCDS57121

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas