Version 5.4
Bos taurus Gene: ATRIP
Summary
InnateDB Gene IDBG-646134.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATRIP
Gene Name ATR-interacting protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000008399
Encoded Proteins
IDBP-698908
ATR-interacting protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164053:
This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:51971832-51989358
Strand Reverse strand
Band
Transcripts
ENSBTAT00000054868 ENSBTAP00000048150
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0015630 microtubule cytoskeleton
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000164053
View Gene Order
ENSMUSG00000025646
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_6769
Activation of ATR in response to replication stress pathway
REACT_897
G2/M DNA damage checkpoint pathway
REACT_147841
STING mediated induction of host immune responses pathway
REACT_163993
IRF3-mediated induction of type I IFN pathway
REACT_6802
Innate Immune System pathway
REACT_828
G2/M Checkpoints pathway
REACT_163977
Regulation of innate immune responses to cytosolic DNA pathway
REACT_115566
Cell Cycle pathway
REACT_6900
Immune System pathway
REACT_163652
Regulation by TREX1 pathway
REACT_118823
Cytosolic sensors of pathogen-associated DNA pathway
REACT_1538
Cell Cycle Checkpoints pathway
REACT_251223
G2/M DNA damage checkpoint pathway
REACT_188804
Cell Cycle pathway
REACT_256025
Cell Cycle Checkpoints pathway
REACT_235397
G2/M Checkpoints pathway
REACT_232236
Activation of ATR in response to replication stress pathway
KEGG
hsa04623
Cytosolic DNA-sensing pathway pathway
INOH
PID NCI
fanconi_pathway
Fanconi anemia pathway
atr_pathway
ATR signaling pathway
Cross-References
SwissProt
TrEMBL A5D7S1
UniProt Splice Variant
Entrez Gene 100125287
UniGene Bt.103089
RefSeq NM_001103330 XM_005222698 XM_005222699
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC140661 DAAA02054432
GenPept AAI40662
RNA Seq Atlas 100125287

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca