InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ATRIP

Summary

InnateDB Gene

IDBG-32700.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATRIP

Gene Name

ATR interacting protein

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000164053

Encoded Proteins

IDBP-32702

ATR interacting protein

IDBP-32704

ATR interacting protein

IDBP-32706

ATR interacting protein

IDBP-375980

ATR interacting protein

IDBP-375986

ATR interacting protein

IDBP-376003

ATR interacting protein

IDBP-376008

ATR interacting protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:48446710-48467644

Strand

Forward strand

Band

p21.31

Transcripts

ENST00000320211	ENSP00000323099
ENST00000357105	ENSP00000349620
ENST00000346691	ENSP00000302338
ENST00000454733	ENSP00000402340
ENST00000421175	ENSP00000406664
ENST00000424906	ENSP00000401761
ENST00000412052	ENSP00000400930
ENST00000491468

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	39 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003697	single-stranded DNA binding
GO:0004527	exonuclease activity
GO:0005515	protein binding
GO:0008296	3'-5'-exodeoxyribonuclease activity
GO:0008408	3'-5' exonuclease activity
GO:0008853	exodeoxyribonuclease III activity
GO:0032405	MutLalpha complex binding
GO:0032407	MutSalpha complex binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0000077	DNA damage checkpoint
GO:0000738	DNA catabolic process, exonucleolytic
GO:0006259	DNA metabolic process
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006298	mismatch repair
GO:0006310	DNA recombination
GO:0008219	cell death
GO:0032479	regulation of type I interferon production
GO:0032481	positive regulation of type I interferon production
GO:0045087	innate immune response
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0015630	microtubule cytoskeleton