InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.46809

Summary

InnateDB Gene

IDBG-646288.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.46809

Gene Name

HLA class II histocompatibility antigen gamma chain

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015228

Encoded Proteins

IDBP-699076

CD74 antigen

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000019582:
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:63748885-63756646

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000020261

ENSBTAP00000020261

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0004896	cytokine receptor activity
GO:0005515	protein binding
GO:0019955	cytokine binding
GO:0023026	MHC class II protein complex binding
GO:0035718	macrophage migration inhibitory factor binding
GO:0042289	MHC class II protein binding
GO:0042658	MHC class II protein binding, via antigen binding groove
GO:0044183	protein binding involved in protein folding
GO:0050998	nitric-oxide synthase binding

Biological Process

GO:0001516	prostaglandin biosynthetic process
GO:0001961	positive regulation of cytokine-mediated signaling pathway
GO:0002606	positive regulation of dendritic cell antigen processing and presentation
GO:0002792	negative regulation of peptide secretion
GO:0002830	positive regulation of type 2 immune response
GO:0002906	negative regulation of mature B cell apoptotic process
GO:0006461	protein complex assembly
GO:0006886	intracellular protein transport
GO:0006952	defense response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0008283	cell proliferation
GO:0016064	immunoglobulin mediated immune response
GO:0019882	antigen processing and presentation
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030890	positive regulation of B cell proliferation
GO:0035691	macrophage migration inhibitory factor signaling pathway
GO:0043066	negative regulation of apoptotic process
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045059	positive thymic T cell selection
GO:0045060	negative thymic T cell selection
GO:0045581	negative regulation of T cell differentiation
GO:0045582	positive regulation of T cell differentiation
GO:0048146	positive regulation of fibroblast proliferation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0051085	chaperone mediated protein folding requiring cofactor
GO:0060907	positive regulation of macrophage cytokine production
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0090023	positive regulation of neutrophil chemotaxis
GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production

Cellular Component

GO:0005764	lysosome
GO:0005770	late endosome
GO:0005771	multivesicular body
GO:0005773	vacuole
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0035692	macrophage migration inhibitory factor receptor complex
GO:0035693	NOS2-CD74 complex
GO:0042613	MHC class II protein complex
GO:0070062	extracellular vesicular exosome