Version 5.4
Homo sapiens Gene: CD74
Summary
InnateDB Gene IDBG-53594.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD74
Gene Name CD74 molecule, major histocompatibility complex, class II invariant chain
Synonyms DHLAG; HLADG; Ia-GAMMA; II
Species Homo sapiens
Ensembl Gene ENSG00000019582
Encoded Proteins
IDBP-53596
CD74 molecule, major histocompatibility complex, class II invariant chain
IDBP-53598
CD74 molecule, major histocompatibility complex, class II invariant chain
IDBP-53600
CD74 molecule, major histocompatibility complex, class II invariant chain
IDBP-474063
CD74 molecule, major histocompatibility complex, class II invariant chain
IDBP-485259
CD74 molecule, major histocompatibility complex, class II invariant chain
IDBP-476494
CD74 molecule, major histocompatibility complex, class II invariant chain
IDBP-480953
CD74 molecule, major histocompatibility complex, class II invariant chain
IDBP-479160
CD74 molecule, major histocompatibility complex, class II invariant chain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:150401637-150412929
Strand Reverse strand
Band q33.1
Transcripts
ENST00000377795 ENSP00000367026
ENST00000353334 ENSP00000230685
ENST00000009530 ENSP00000009530
ENST00000518797 ENSP00000430614
ENST00000524315 ENSP00000429024
ENST00000523208 ENSP00000430654
ENST00000517752
ENST00000522246 ENSP00000429641
ENST00000523813 ENSP00000429478
ENST00000523836
ENST00000517791
ENST00000522153
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 13 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001540 beta-amyloid binding
GO:0004896 cytokine receptor activity
GO:0005515 protein binding
GO:0019955 cytokine binding
GO:0023026 MHC class II protein complex binding
GO:0035718 macrophage migration inhibitory factor binding
GO:0042289 MHC class II protein binding
GO:0042658 MHC class II protein binding, via antigen binding groove
GO:0042802 identical protein binding
GO:0044183 protein binding involved in protein folding
GO:0050998 nitric-oxide synthase binding
Biological Process
GO:0000187 activation of MAPK activity
GO:0001516 prostaglandin biosynthetic process
GO:0001961 positive regulation of cytokine-mediated signaling pathway
GO:0002606 positive regulation of dendritic cell antigen processing and presentation
GO:0002792 negative regulation of peptide secretion
GO:0002830 positive regulation of type 2 immune response
GO:0002906 negative regulation of mature B cell apoptotic process
GO:0006461 protein complex assembly
GO:0006886 intracellular protein transport
GO:0006952 defense response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0008283 cell proliferation
GO:0016064 immunoglobulin mediated immune response
GO:0019882 antigen processing and presentation
GO:0019883 antigen processing and presentation of endogenous antigen
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030890 positive regulation of B cell proliferation
GO:0035691 macrophage migration inhibitory factor signaling pathway
GO:0043030 regulation of macrophage activation
GO:0043066 negative regulation of apoptotic process
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045058 T cell selection
GO:0045059 positive thymic T cell selection
GO:0045060 negative thymic T cell selection
GO:0045581 negative regulation of T cell differentiation
GO:0045582 positive regulation of T cell differentiation
GO:0048146 positive regulation of fibroblast proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051085 chaperone mediated protein folding requiring cofactor
GO:0060907 positive regulation of macrophage cytokine production
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090023 positive regulation of neutrophil chemotaxis
GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production
Cellular Component
GO:0000139 Golgi membrane
GO:0005622 intracellular
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005770 late endosome
GO:0005771 multivesicular body
GO:0005773 vacuole
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030658 transport vesicle membrane
GO:0030666 endocytic vesicle membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0032588 trans-Golgi network membrane
GO:0035692 macrophage migration inhibitory factor receptor complex
GO:0035693 NOS2-CD74 complex
GO:0042613 MHC class II protein complex
GO:0043202 lysosomal lumen
GO:0070062 extracellular vesicular exosome
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024610
View Gene Order
ENSBTAG00000015228
Not yet available
Pathways
NETPATH
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04612
Antigen processing and presentation pathway
INOH
PID NCI
Cross-References
SwissProt P04233
TrEMBL O19685 O78208
UniProt Splice Variant
Entrez Gene 972
UniGene Hs.436568
RefSeq NM_001025159 NM_001025158 NM_004355
HUGO HGNC:1697
OMIM 142790
CCDS CCDS47309 CCDS34276 CCDS47308
HPRD 00825
IMGT
EMBL AC011372 AC011388 AK292076 AK297889 BC018726 BC024272 BT019505 CH471062 K01144 M13555 M13556 M13558 M13559 M13560 M28588 M28590 X00497 X03339 X03340
GenPept AAA35996 AAA36033 AAA36304 AAA58655 AAH18726 AAH24272 AAV38312 BAF84765 BAG60210 CAA25192 CAA25193 CAA27046 CAA27047 EAW61727 EAW61728 EAW61729 EAW61730 EAW61731
RNA Seq Atlas 972

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca