InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ANXA6

Summary

InnateDB Gene

IDBG-646320.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANXA6

Gene Name

Annexin A6

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014809

Encoded Proteins

IDBP-699115

Annexin A6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197043:
Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:64359563-64406299

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000019719

ENSBTAP00000019719

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005262	calcium channel activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0005544	calcium-dependent phospholipid binding
GO:0008201	heparin binding
GO:0008289	lipid binding
GO:0015276	ligand-gated ion channel activity
GO:0015485	cholesterol binding
GO:0019899	enzyme binding
GO:0035374	chondroitin sulfate binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0048306	calcium-dependent protein binding
GO:0051015	actin filament binding

Biological Process

GO:0003418	growth plate cartilage chondrocyte differentiation
GO:0006816	calcium ion transport
GO:0006937	regulation of muscle contraction
GO:0031214	biomineral tissue development
GO:0034220	ion transmembrane transport
GO:0051260	protein homooligomerization
GO:0070509	calcium ion import

Cellular Component

GO:0001725	stress fiber
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030061	mitochondrial crista
GO:0031902	late endosome membrane
GO:0031988	membrane-bounded vesicle
GO:0042470	melanosome
GO:0042584	chromaffin granule membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000197043

View Gene Order

ENSMUSG00000018340

View Gene Order

Cross-References

SwissProt

P79134

TrEMBL

UniProt Splice Variant

Entrez Gene

327685

UniGene

Bt.5267

RefSeq

NM_001103224 XM_005209561 XM_005209562 XM_005209563

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC151391 U87539

GenPept

AAB47570 AAI51392

RNA Seq Atlas

327685