InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SLC12A1

Summary

InnateDB Gene

IDBG-646682.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC12A1

Gene Name

Uncharacterized protein

Synonyms

BSC1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010145

Encoded Proteins

IDBP-699509

solute carrier family 12 (sodium/potassium/chloride transporters), member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000074803:
This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.[provided by RefSeq, May 2010]
This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle\'s loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.[provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:62319877-62405827

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000046583

ENSBTAP00000043868

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0015377	cation:chloride symporter activity

Biological Process

GO:0001822	kidney development
GO:0006810	transport
GO:0006811	ion transport
GO:0006821	chloride transport
GO:0007588	excretion
GO:0048878	chemical homeostasis
GO:0055085	transmembrane transport
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000074803

View Gene Order

ENSMUSG00000027202

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_19315

Cation-coupled Chloride cotransporters pathway

REACT_19397

Transport of inorganic cations/anions and amino acids/oligopeptides pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_19118

SLC-mediated transmembrane transport pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

F1MS75

UniProt Splice Variant

Entrez Gene

407161

UniGene

RefSeq

XM_005211899

HUGO

HGNC:10910

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02029124 DAAA02029125

GenPept

RNA Seq Atlas

407161