Version 5.4
Bos taurus Gene: ZFP36L1
Summary
InnateDB Gene IDBG-646800.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZFP36L1
Gene Name zinc finger protein 36, C3H1 type-like 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000025434
Encoded Proteins
IDBP-699636
butyrate response factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185650:
This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:80965364-80970846
Strand Reverse strand
Band
Transcripts
ENSBTAT00000035742 ENSBTAP00000035611
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0001570 vasculogenesis
GO:0006417 regulation of translation
GO:0033077 T cell differentiation in thymus
GO:0043488 regulation of mRNA stability
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000185650
View Gene Order
ENSMUSG00000021127
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_24915
Butyrate Response Factor 1 (BRF1) destabilizes mRNA pathway
REACT_24994
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_71
Gene Expression pathway
REACT_198687
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_198695
Butyrate Response Factor 1 (BRF1) destabilizes mRNA pathway
REACT_233572
Gene Expression pathway
KEGG
INOH
PID NCI
myc_represspathway
Validated targets of C-MYC transcriptional repression
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.61758 Bt.97767
RefSeq NM_001101234 XM_005212043
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca