InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ZFP36L1

Summary

InnateDB Gene

IDBG-10189.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZFP36L1

Gene Name

zinc finger protein 36, C3H type-like 1

Synonyms

Berg36; BRF1; cMG1; ERF-1; ERF1; RNF162B; TIS11B

Species

Homo sapiens

Ensembl Gene

ENSG00000185650

Encoded Proteins

IDBP-10191

zinc finger protein 36, C3H type-like 1

IDBP-373037

zinc finger protein 36, C3H type-like 1

IDBP-590555

zinc finger protein 36, C3H type-like 1

IDBP-583600

zinc finger protein 36, C3H type-like 1

IDBP-593247

zinc finger protein 36, C3H type-like 1

IDBP-596931

zinc finger protein 36, C3H type-like 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:68787660-68796253

Strand

Reverse strand

Band

q24.1

Transcripts

ENST00000336440	ENSP00000337386
ENST00000439696	ENSP00000388402
ENST00000555997	ENSP00000451093
ENST00000557086	ENSP00000450784
ENST00000557022	ENSP00000450600
ENST00000553375	ENSP00000452119

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0001570	vasculogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0006417	regulation of translation
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0033077	T cell differentiation in thymus
GO:0043488	regulation of mRNA stability

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000021127

View Gene Order

ENSBTAG00000025434

Not yet available

Pathways

NETPATH

REACTOME

REACT_24915

Butyrate Response Factor 1 (BRF1) destabilizes mRNA pathway

REACT_24994

Regulation of mRNA stability by proteins that bind AU-rich elements pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

myc_represspathway

Validated targets of C-MYC transcriptional repression

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.605465 Hs.655774 Hs.707091 Hs.732674 Hs.734777 Hs.85155

RefSeq

NM_001244698 NM_001244701 NM_004926

HUGO

OMIM

CCDS

CCDS9791

HPRD

03041

IMGT

EMBL

GenPept

RNA Seq Atlas