Version 5.4
Bos taurus Gene: DLST
Summary
InnateDB Gene IDBG-646860.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DLST
Gene Name dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000006463
Encoded Proteins
IDBP-699699
dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119689:
This gene encodes a mitochondrial protein that belongs to the 2-oxoacid dehydrogenase family. This protein is one of the three components (the E2 component) of the 2-oxoglutarate dehydrogenase complex that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:86533853-86550983
Strand Forward strand
Band
Transcripts
ENSBTAT00000008473 ENSBTAP00000008473
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004149 dihydrolipoyllysine-residue succinyltransferase activity
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0008152 metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0016020 membrane
GO:0045252 oxoglutarate dehydrogenase complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000119689
View Gene Order
ENSMUSG00000004789
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1298
Lysine catabolism pathway
REACT_1785
Citric acid cycle (TCA cycle) pathway
REACT_1046
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
REACT_189162
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
REACT_241308
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_239844
Lysine catabolism pathway
REACT_249033
Citric acid cycle (TCA cycle) pathway
KEGG
hsa00020
Citrate cycle (TCA cycle) pathway
hsa00310
Lysine degradation pathway
mmu00310
Lysine degradation pathway
mmu00020
Citrate cycle (TCA cycle) pathway
INOH
INOH website
Citrate cycle pathway
PID NCI
Cross-References
SwissProt
TrEMBL F1MEQ3
UniProt Splice Variant
Entrez Gene 506888
UniGene
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02029614 DAAA02029615 DAAA02029616 DAAA02029617
GenPept
RNA Seq Atlas 506888

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca