Version 5.4
Bos taurus Gene: DIO2
Summary
InnateDB Gene IDBG-646906.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DIO2
Gene Name type II iodothyronine deiodinase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000001605
Encoded Proteins
IDBP-699754
type II iodothyronine deiodinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000211448:
The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3\',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3\' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:92624410-92632934
Strand Reverse strand
Band
Transcripts
ENSBTAT00000002107 ENSBTAP00000002107
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004800 thyroxine 5'-deiodinase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0042404 thyroid hormone catabolic process
GO:0042446 hormone biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000211448
View Gene Order
ENSMUSG00000007682
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_15292
Thyroxine biosynthesis pathway
REACT_15513
Amine-derived hormones pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_15297
Regulation of thyroid hormone activity pathway
REACT_111217
Metabolism pathway
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
REACT_210325
Regulation of thyroid hormone activity pathway
REACT_219697
Thyroxine biosynthesis pathway
REACT_215158
Amine-derived hormones pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1N5X5 Q5I3B0
UniProt Splice Variant
Entrez Gene 494548
UniGene Bt.63066
RefSeq NM_001010992
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AH014576 DAAA02029819
GenPept AAW51122
RNA Seq Atlas 494548

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca