Version 5.4
Homo sapiens Gene: DIO2
Summary
InnateDB Gene IDBG-14346.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DIO2
Gene Name deiodinase, iodothyronine, type II
Synonyms 5DII; D2; DIOII; SelY; TXDI2
Species Homo sapiens
Ensembl Gene ENSG00000211448
Encoded Proteins
IDBP-375044
deiodinase, iodothyronine, type II
IDBP-375045
deiodinase, iodothyronine, type II
IDBP-592352
deiodinase, iodothyronine, type II
IDBP-603121
deiodinase, iodothyronine, type II
IDBP-600416
deiodinase, iodothyronine, type II
IDBP-588813
deiodinase, iodothyronine, type II
IDBP-603053
deiodinase, iodothyronine, type II
IDBP-588732
deiodinase, iodothyronine, type II
IDBP-589954
deiodinase, iodothyronine, type II
IDBP-600287
deiodinase, iodothyronine, type II
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3\',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3\' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:80197527-80387757
Strand Reverse strand
Band q31.1
Transcripts
ENST00000422005 ENSP00000411438
ENST00000438257 ENSP00000405854
ENST00000557010 ENSP00000451419
ENST00000556811 ENSP00000451971
ENST00000555750 ENSP00000450980
ENST00000557125 ENSP00000450547
ENST00000555844 ENSP00000450781
ENST00000554188 ENSP00000451136
ENST00000553968 ENSP00000451339
ENST00000553594 ENSP00000451265
ENST00000556384
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004800 thyroxine 5'-deiodinase activity
GO:0008430 selenium binding
GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0001514 selenocysteine incorporation
GO:0006590 thyroid hormone generation
GO:0034641 cellular nitrogen compound metabolic process
GO:0042403 thyroid hormone metabolic process
GO:0042404 thyroid hormone catabolic process
GO:0042446 hormone biosynthetic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000007682
View Gene Order
ENSBTAG00000001605
Not yet available
Pathways
NETPATH
REACTOME
REACT_15292
Thyroxine biosynthesis pathway
REACT_15513
Amine-derived hormones pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_15297
Regulation of thyroid hormone activity pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q92813
TrEMBL A8K845 G3V3A8 Q9C0K2 Q9NZL0
UniProt Splice Variant
Entrez Gene 1734
UniGene Hs.202354 Hs.629043 Hs.708526 Hs.732170
RefSeq NM_013989 NM_000793 NM_001007023 NM_001242502 NM_001242503
HUGO HGNC:2884
OMIM 601413
CCDS CCDS45146 CCDS55934
HPRD 09027
IMGT
EMBL AB039888 AB041843 AC007372 AC010849 AF093774 AF188709 AK292210 AL049837 BC074882 BC136514 U53506
GenPept AAC50663 AAC95470 AAD45494 AAF37612 AAH74882 AAI36515 BAB16838 BAB21594 BAF84899
RNA Seq Atlas 1734

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca