Version 5.4
Homo sapiens Gene: STX2
Summary
InnateDB Gene IDBG-64736.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STX2
Gene Name syntaxin 2
Synonyms EPIM; EPM; STX2A; STX2B; STX2C
Species Homo sapiens
Ensembl Gene ENSG00000111450
Encoded Proteins
IDBP-64738
syntaxin 2
IDBP-64740
syntaxin 2
IDBP-245790
syntaxin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:130789600-130839266
Strand Reverse strand
Band q24.33
Transcripts
ENST00000344271 ENSP00000342554
ENST00000261653 ENSP00000261653
ENST00000392373 ENSP00000376178
ENST00000540889
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005484 SNAP receptor activity
GO:0005515 protein binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0006886 intracellular protein transport
GO:0007165 signal transduction
GO:0007340 acrosome reaction
GO:0007398 ectoderm development
GO:0009887 organ morphogenesis
GO:0010468 regulation of gene expression
GO:0016192 vesicle-mediated transport
GO:0030154 cell differentiation
GO:0030193 regulation of blood coagulation
Cellular Component
GO:0005911 cell-cell junction
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0043231 intracellular membrane-bounded organelle
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029428
View Gene Order
ENSBTAG00000007988
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04130
SNARE interactions in vesicular transport pathway
INOH
PID NCI
Cross-References
SwissProt P32856
TrEMBL
UniProt Splice Variant
Entrez Gene 2054
UniGene
RefSeq NM_001980 NM_194356 XM_005253556
HUGO HGNC:3403
OMIM 132350
CCDS CCDS9269 CCDS9270
HPRD
IMGT
EMBL AC073912 BC047496 D14582
GenPept AAH47496 BAA03436
RNA Seq Atlas 2054

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca