Homo sapiens Gene: DCDC2
Summary
InnateDB Gene IDBG-64753.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCDC2
Gene Name doublecortin domain containing 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000146038
Encoded Proteins
doublecortin domain containing 2
doublecortin domain containing 2
doublecortin domain containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a doublecortin domain-containing family member. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. This family member is thought to function in neuronal migration where it may affect the signaling of primary cilia. Mutations in this gene have been associated with reading disability (RD) type 2, also referred to as developmental dyslexia. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:24171756-24358052
Strand Reverse strand
Band p22.3
Transcripts
ENST00000378454 ENSP00000367715
ENST00000378450 ENSP00000367711
ENST00000436313 ENSP00000410939
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0001764 neuron migration
GO:0006968 cellular defense response
GO:0008542 visual learning
GO:0035556 intracellular signal transduction
GO:0048813 dendrite morphogenesis
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q9UHG0
TrEMBL
UniProt Splice Variant
Entrez Gene 51473
UniGene Hs.61345 Hs.618980
RefSeq NM_001195610 NM_016356
HUGO HGNC:18141
OMIM 605755
CCDS CCDS4550
HPRD
IMGT
EMBL AB032980 AF181720 AF181721 AL133043 AL359389 AL359713 BC050704 FO393410
GenPept AAF23610 AAF23612 AAH50704 BAA86468 CAB61371
RNA Seq Atlas 51473