Homo sapiens Gene: PLD1
Summary
InnateDB Gene IDBG-64867.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLD1
Gene Name phospholipase D1, phosphatidylcholine-specific
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000075651
Encoded Proteins
phospholipase D1, phosphatidylcholine-specific
phospholipase D1, phosphatidylcholine-specific
phospholipase D1, phosphatidylcholine-specific
phospholipase D1, phosphatidylcholine-specific
phospholipase D1, phosphatidylcholine-specific
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory properties. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:171600405-171810950
Strand Reverse strand
Band q26.31
Transcripts
ENST00000356327 ENSP00000348681
ENST00000351298 ENSP00000342793
ENST00000446289 ENSP00000395556
ENST00000440204 ENSP00000391164
ENST00000418087 ENSP00000400639
ENST00000463281
ENST00000465816
ENST00000467432
ENST00000471075
ENST00000481505
ENST00000498278
ENST00000475273
ENST00000489995
ENST00000460926
ENST00000497307
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
Experimentally validated
Total 35 [view]
Protein-Protein 33 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004630 phospholipase D activity
GO:0005515 protein binding
GO:0035091 phosphatidylinositol binding
GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006654 phosphatidic acid biosynthetic process
GO:0006655 phosphatidylglycerol biosynthetic process
GO:0006935 chemotaxis
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0008152 metabolic process
GO:0016042 lipid catabolic process
GO:0044281 small molecule metabolic process
GO:0046474 glycerophospholipid biosynthetic process
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0000139 Golgi membrane
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0031902 late endosome membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
REACTOME
Metabolism of lipids and lipoproteins pathway
Innate Immune System pathway
Glycerophospholipid biosynthesis pathway
Role of phospholipids in phagocytosis pathway
Immune System pathway
Synthesis of PA pathway
Phospholipid metabolism pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Metabolism pathway
Synthesis of PG pathway
KEGG
Glycerophospholipid metabolism pathway
Ether lipid metabolism pathway
Endocytosis pathway
Fc gamma R-mediated phagocytosis pathway
GnRH signaling pathway pathway
Pathways in cancer pathway
Pancreatic cancer pathway
INOH
PID BIOCARTA
Ras signaling pathway [Biocarta view]
Metabolism of anandamide an endogenous cannabinoid [Biocarta view]
Rac1 cell motility signaling pathway [Biocarta view]
PID NCI
Alpha-synuclein signaling
IL8- and CXCR1-mediated signaling events
ErbB1 downstream signaling
CDC42 signaling events
Cross-References
SwissProt Q13393
TrEMBL C9IY79 F8WBV7 Q59EA4 Q8WYW5
UniProt Splice Variant
Entrez Gene 5337
UniGene Hs.382865 Hs.592715 Hs.600897 Hs.705837 Hs.732969
RefSeq NM_001130081 NM_002662 XM_005247533 XM_005247534
HUGO HGNC:9067
OMIM 602382
CCDS CCDS3216 CCDS46957
HPRD
IMGT
EMBL AB209907 AC008134 AC078953 AF318333 AJ276230 BC068976 U38545
GenPept AAB49031 AAH68976 AAL55840 BAD93144 CAB76564
RNA Seq Atlas 5337