InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLD1

Summary

InnateDB Protein

IDBP-64873.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLD1

Protein Name

phospholipase D1, phosphatidylcholine-specific

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000342793

InnateDB Gene

IDBG-64867 (PLD1)

Protein Structure

UniProt Annotation

Function

Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Late endosome membrane {ECO:0000250}; Lipid- anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed abundantly in the pancreas and heart and at high levels in brain, placenta, spleen, uterus and small intestine. {ECO:0000269PubMed:9582313}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.

Experimentally validated
Total	35 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004630	phospholipase D activity
GO:0005515	protein binding
GO:0035091	phosphatidylinositol binding
GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006654	phosphatidic acid biosynthetic process
GO:0006655	phosphatidylglycerol biosynthetic process
GO:0006935	chemotaxis
GO:0007264	small GTPase mediated signal transduction
GO:0007265	Ras protein signal transduction
GO:0008152	metabolic process
GO:0016042	lipid catabolic process
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process
GO:0050830	defense response to Gram-positive bacterium

Cellular Component

GO:0000139	Golgi membrane
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0031902	late endosome membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001683 Phox homologous domain
IPR001736 Phospholipase D/Transphosphatidylase
IPR001849 Pleckstrin homology domain
IPR016555 Phospholipase D, eukaryota

PFAM

PF00787
PF00614
PF00169

PRINTS

PIRSF

PIRSF009376

SMART

SM00312
SM00155
SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt