InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GPER

Summary

InnateDB Gene

IDBG-648741.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPER

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000048154

Encoded Proteins

IDBP-701459

G protein-coupled estrogen receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164850:
This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:42259657-42260709

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000063015

ENSBTAP00000056477

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0005496	steroid binding
GO:0005515	protein binding
GO:0030284	estrogen receptor activity

Biological Process

GO:0002695	negative regulation of leukocyte activation
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0008284	positive regulation of cell proliferation
GO:0010579	positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030335	positive regulation of cell migration
GO:0030518	intracellular steroid hormone receptor signaling pathway
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0032024	positive regulation of insulin secretion
GO:0032962	positive regulation of inositol trisphosphate biosynthetic process
GO:0043401	steroid hormone mediated signaling pathway
GO:0043410	positive regulation of MAPK cascade
GO:0045599	negative regulation of fat cell differentiation
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway
GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050728	negative regulation of inflammatory response
GO:0050769	positive regulation of neurogenesis
GO:0051055	negative regulation of lipid biosynthetic process
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0070474	positive regulation of uterine smooth muscle contraction
GO:0071157	negative regulation of cell cycle arrest
GO:0071333	cellular response to glucose stimulus
GO:0071356	cellular response to tumor necrosis factor
GO:0071375	cellular response to peptide hormone stimulus
GO:0071392	cellular response to estradiol stimulus
GO:0090004	positive regulation of establishment of protein localization to plasma membrane

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0045095	keratin filament
GO:0048471	perinuclear region of cytoplasm
GO:0055037	recycling endosome