Homo sapiens Gene: CLTA
Summary
InnateDB Gene IDBG-64915.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLTA
Gene Name clathrin, light chain A
Synonyms LCA;
Species Homo sapiens
Ensembl Gene ENSG00000122705
Encoded Proteins
clathrin, light chain A
clathrin, light chain A
clathrin, light chain A
clathrin, light chain A
clathrin, light chain A
clathrin, light chain A
clathrin, light chain A
clathrin, light chain A
clathrin, light chain A
clathrin, light chain A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:36190856-36304781
Strand Forward strand
Band p13.3
Transcripts
ENST00000345519 ENSP00000242284
ENST00000242285 ENSP00000242285
ENST00000396603 ENSP00000379848
ENST00000433436 ENSP00000401019
ENST00000464497 ENSP00000419158
ENST00000470744 ENSP00000419746
ENST00000466396 ENSP00000417698
ENST00000493185 ENSP00000474266
ENST00000538225 ENSP00000442869
ENST00000540080 ENSP00000437508
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
Experimentally validated
Total 32 [view]
Protein-Protein 31 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0032050 clathrin heavy chain binding
GO:0042277 peptide binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006892 post-Golgi vesicle-mediated transport
GO:0006897 endocytosis
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007411 axon guidance
GO:0016192 vesicle-mediated transport
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0061024 membrane organization
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005905 coated pit
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030118 clathrin coat
GO:0030130 clathrin coat of trans-Golgi network vesicle
GO:0030132 clathrin coat of coated pit
GO:0030136 clathrin-coated vesicle
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0032588 trans-Golgi network membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0071439 clathrin complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
EGFR1 pathway
REACTOME
PCP/CE pathway pathway
MHC class II antigen presentation pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Gap junction degradation pathway
WNT5A-dependent internalization of FZD4 pathway
beta-catenin independent WNT signaling pathway
Formation of annular gap junctions pathway
Signaling by Wnt pathway
Signaling by EGFR pathway
Axon guidance pathway
Signal Transduction pathway
Gap junction trafficking pathway
Recycling pathway of L1 pathway
Adaptive Immune System pathway
Immune System pathway
NGF signalling via TRKA from the plasma membrane pathway
Retrograde neurotrophin signalling pathway
L1CAM interactions pathway
EPH-ephrin mediated repulsion of cells pathway
EGFR downregulation pathway
EPH-Ephrin signaling pathway
Gap junction trafficking and regulation pathway
Disease pathway
Membrane Trafficking pathway
KEGG
Lysosome pathway
Endocytosis pathway
Huntington's disease pathway
Bacterial invasion of epithelial cells pathway
INOH
PID BIOCARTA
Adp-ribosylation factor [Biocarta view]
PID NCI
Arf1 pathway
C-MYB transcription factor network
Cross-References
SwissProt P09496
TrEMBL
UniProt Splice Variant
Entrez Gene 1211
UniGene Hs.629185 Hs.735741
RefSeq NM_001184760 NM_001184761 NM_001833 NM_007096 NM_001076677 NM_001184762
HUGO HGNC:2090
OMIM 118960
CCDS CCDS55306 CCDS6600 CCDS6601 CCDS43802 CCDS55307
HPRD 00351
IMGT
EMBL AK291078 AK295692 AL158830 AL161792 BC009201 BC019287 BT007170 CH471071 DQ270158 M20471 M20472
GenPept AAA51817 AAA59505 AAH09201 AAH19287 AAP35834 ABB76683 BAF83767 BAG58543 CAD13387 CAD13388 EAW58312
RNA Seq Atlas 1211