InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CLTA

Summary

InnateDB Protein

IDBP-237159.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLTA

Protein Name

clathrin, light chain A

Synonyms

LCA;

Species

Homo sapiens

Ensembl Protein

ENSP00000379848

InnateDB Gene

IDBG-64915 (CLTA)

Protein Structure

UniProt Annotation

Function

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.

Subcellular Localization

Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.

Experimentally validated
Total	32 [view]
Protein-Protein	31 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0032050	clathrin heavy chain binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006892	post-Golgi vesicle-mediated transport
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007411	axon guidance
GO:0016192	vesicle-mediated transport
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0061024	membrane organization

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030118	clathrin coat
GO:0030130	clathrin coat of trans-Golgi network vesicle
GO:0030132	clathrin coat of coated pit
GO:0030669	clathrin-coated endocytic vesicle membrane
GO:0032588	trans-Golgi network membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0071439	clathrin complex