Homo sapiens Gene: RGS9
Summary
InnateDB Gene IDBG-65027.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RGS9
Gene Name regulator of G-protein signaling 9
Synonyms PERRS; RGS9L;
Species Homo sapiens
Ensembl Gene ENSG00000108370
Encoded Proteins
regulator of G-protein signaling 9
regulator of G-protein signaling 9
regulator of G-protein signaling 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the RGS family of GTPase activating proteins that function in various signaling pathways by accelerating the deactivation of G proteins. This protein is anchored to photoreceptor membranes in retinal cells and deactivates G proteins in the rod and cone phototransduction cascades. Mutations in this gene result in bradyopsia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:65137431-65227703
Strand Forward strand
Band q24.1
Transcripts
ENST00000262406 ENSP00000262406
ENST00000449996 ENSP00000396329
ENST00000443584 ENSP00000405814
ENST00000581175
ENST00000583473
ENST00000577186
ENST00000584234 ENSP00000463410
ENST00000577595
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005096 GTPase activator activity
GO:0032403 protein complex binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007212 dopamine receptor signaling pathway
GO:0007399 nervous system development
GO:0007601 visual perception
GO:0007603 phototransduction, visible light
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0016056 rhodopsin mediated signaling pathway
GO:0022400 regulation of rhodopsin mediated signaling pathway
GO:0035556 intracellular signal transduction
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043547 positive regulation of GTPase activity
GO:0043627 response to estrogen
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
KEGG
Phototransduction pathway
INOH
GPCR signaling pathway
PID BIOCARTA
PID NCI
Visual signal transduction: Cones
Visual signal transduction: Rods
Cross-References
SwissProt O75916
TrEMBL E9PD91 J3QL70
UniProt Splice Variant
Entrez Gene 8787
UniGene Hs.664380
RefSeq NM_001081955 NM_001165933 NM_003835
HUGO HGNC:10004
OMIM 604067
CCDS CCDS42373 CCDS45764
HPRD
IMGT
EMBL AC015821 AC060771 AF071476 AF073710 AF178056 AF178057 AF178058 AF178059 AF178060 AF178061 AF178062 AF178063 AF178064 AF178065 AF178066 AF178067 AF178068 AF178069 AF178070 AF178071 AF178072 AF493932 AF493933 AK290535 AY585190 AY585191 CH471099
GenPept AAC25430 AAC64040 AAG09311 AAG09312 AAM12646 AAM12647 AAT79493 AAT79494 BAF83224 EAW88998
RNA Seq Atlas 8787