InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KIF3B

Summary

InnateDB Gene

IDBG-65047.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIF3B

Gene Name

kinesin family member 3B

Synonyms

FLA8; HH0048; KLP-11;

Species

Homo sapiens

Ensembl Gene

ENSG00000101350

Encoded Proteins

IDBP-65049

kinesin family member 3B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene acts as a heterodimer with kinesin family member 3A to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. This protein and kinesin family member 3A form the kinesin II subfamily of the kinesin superfamily. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:32277664-32335011

Strand

Forward strand

Band

q11.21

Transcripts

ENST00000375712

ENSP00000364864

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	18 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0008574	plus-end-directed microtubule motor activity
GO:0017048	Rho GTPase binding

Biological Process

GO:0007018	microtubule-based movement
GO:0007052	mitotic spindle organization
GO:0007100	mitotic centrosome separation
GO:0007368	determination of left/right symmetry
GO:0007596	blood coagulation
GO:0008089	anterograde axon cargo transport
GO:0008152	metabolic process
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0032467	positive regulation of cytokinesis
GO:0061024	membrane organization
GO:0072383	plus-end-directed vesicle transport along microtubule
GO:0090307	spindle assembly involved in mitosis

Cellular Component

GO:0005813	centrosome
GO:0005819	spindle
GO:0005829	cytosol
GO:0005873	plus-end kinesin complex
GO:0005876	spindle microtubule
GO:0005929	cilium
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0016939	kinesin II complex
GO:0030496	midbody
GO:0030990	intraciliary transport particle
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

Method

Confidence

Comments

ENSMUSG00000027475

View Gene Order

Ortholuge

SSD Ortholog

Ortholog supports species divergence

ENSBTAG00000003215

Not yet available

Ortholuge

SSD Ortholog

Ortholog supports species divergence

Pathways

NETPATH

REACTOME

REACT_121399

MHC class II antigen presentation pathway

REACT_25201

Kinesins pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_147867

Translocation of GLUT4 to the plasma membrane pathway

REACT_24970

Factors involved in megakaryocyte development and platelet production pathway

REACT_604

Hemostasis pathway

REACT_11123

Membrane Trafficking pathway

KEGG

INOH

PID BIOCARTA

PID NCI

Cross-References

SwissProt

O15066

TrEMBL

UniProt Splice Variant

Entrez Gene

9371

UniGene

Hs.369670

RefSeq

NM_004798

HUGO

HGNC:6320

OMIM

603754

CCDS

CCDS13200

HPRD

IMGT

EMBL

AB002357 AL121897 BC136310 BC136311 CH471077

GenPept

AAI36311 AAI36312 BAA20815 CAC16425 EAW76381 EAW76382

RNA Seq Atlas

9371