Homo sapiens Gene: KIF3B
Summary
InnateDB Gene IDBG-65047.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KIF3B
Gene Name kinesin family member 3B
Synonyms FLA8; HH0048; KLP-11;
Species Homo sapiens
Ensembl Gene ENSG00000101350
Encoded Proteins
kinesin family member 3B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene acts as a heterodimer with kinesin family member 3A to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. This protein and kinesin family member 3A form the kinesin II subfamily of the kinesin superfamily. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:32277664-32335011
Strand Forward strand
Band q11.21
Transcripts
ENST00000375712 ENSP00000364864
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 18 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003777 microtubule motor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0008574 plus-end-directed microtubule motor activity
GO:0017048 Rho GTPase binding
Biological Process
GO:0007018 microtubule-based movement
GO:0007052 mitotic spindle organization
GO:0007100 mitotic centrosome separation
GO:0007368 determination of left/right symmetry
GO:0007596 blood coagulation
GO:0008089 anterograde axon cargo transport
GO:0008152 metabolic process
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0032467 positive regulation of cytokinesis
GO:0061024 membrane organization
GO:0072383 plus-end-directed vesicle transport along microtubule
GO:0090307 spindle assembly involved in mitosis
Cellular Component
GO:0005813 centrosome
GO:0005819 spindle
GO:0005829 cytosol
GO:0005873 plus-end kinesin complex
GO:0005876 spindle microtubule
GO:0005929 cilium
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0016939 kinesin II complex
GO:0030496 midbody
GO:0030990 intraciliary transport particle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
MHC class II antigen presentation pathway
Kinesins pathway
Adaptive Immune System pathway
Immune System pathway
Translocation of GLUT4 to the plasma membrane pathway
Factors involved in megakaryocyte development and platelet production pathway
Hemostasis pathway
Membrane Trafficking pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O15066
TrEMBL
UniProt Splice Variant
Entrez Gene 9371
UniGene Hs.369670
RefSeq NM_004798
HUGO HGNC:6320
OMIM 603754
CCDS CCDS13200
HPRD
IMGT
EMBL AB002357 AL121897 BC136310 BC136311 CH471077
GenPept AAI36311 AAI36312 BAA20815 CAC16425 EAW76381 EAW76382
RNA Seq Atlas 9371