Homo sapiens Gene: CACNG4
Summary
InnateDB Gene IDBG-65281.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CACNG4
Gene Name calcium channel, voltage-dependent, gamma subunit 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000075461
Encoded Proteins
calcium channel, voltage-dependent, gamma subunit 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:66964910-67033398
Strand Forward strand
Band q24.2
Transcripts
ENST00000262138 ENSP00000262138
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005245 voltage-gated calcium channel activity
Biological Process
GO:0006810 transport
GO:0007268 synaptic transmission
GO:0019226 transmission of nerve impulse
GO:0051899 membrane depolarization
GO:0070588 calcium ion transmembrane transport
GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0016021 integral component of membrane
GO:0030666 endocytic vesicle membrane
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Neuronal System pathway
Trafficking of AMPA receptors pathway
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels pathway
Transmission across Chemical Synapses pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
KEGG
MAPK signaling pathway pathway
Cardiac muscle contraction pathway
Hypertrophic cardiomyopathy (HCM) pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
Dilated cardiomyopathy pathway
INOH
GPCR Dopamine D1like receptor signaling pathway pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9UBN1
TrEMBL A0A024R8J8
UniProt Splice Variant
Entrez Gene 27092
UniGene Hs.514423
RefSeq NM_014405
HUGO HGNC:1408
OMIM 606404
CCDS CCDS11667
HPRD
IMGT
EMBL AF142622 AF142623 AF142624 AF142625 AF162692 AK315149 BC034532 CH471099
GenPept AAF03090 AAF14538 AAH34532 BAG37597 EAW89020 EAW89021
RNA Seq Atlas 27092