Homo sapiens Gene: WDR45
Summary
InnateDB Gene IDBG-65371.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WDR45
Gene Name WD repeat domain 45
Synonyms NBIA4; NBIA5; WDRX1; WIPI-4; WIPI4;
Species Homo sapiens
Ensembl Gene ENSG00000196998
Encoded Proteins
WD repeat domain 45
WD repeat domain 45
WD repeat domain 45
WD repeat domain 45
WD repeat domain 45
WD repeat domain 45
WD repeat domain 45
WD repeat domain 45
WD repeat domain 45
WD repeat domain 45
WD repeat domain 45
WD repeat domain 45
WD repeat domain 45
WD repeat domain 45
WD repeat domain 45
WD repeat domain 45
WD repeat domain 45
WD repeat domain 45
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:49074433-49101170
Strand Reverse strand
Band p11.23
Transcripts
ENST00000356463 ENSP00000348848
ENST00000376372 ENSP00000365551
ENST00000376368 ENSP00000365546
ENST00000322995 ENSP00000365543
ENST00000376357
ENST00000367375 ENSP00000356345
ENST00000396681 ENSP00000379913
ENST00000433252
ENST00000419567 ENSP00000393640
ENST00000423215 ENSP00000397657
ENST00000465806
ENST00000486337 ENSP00000419453
ENST00000485908 ENSP00000419897
ENST00000473974 ENSP00000417211
ENST00000475977 ENSP00000417754
ENST00000480412
ENST00000471338 ENSP00000418466
ENST00000472654
ENST00000475880 ENSP00000418919
ENST00000474053 ENSP00000420728
ENST00000476728 ENSP00000419324
ENST00000465382 ENSP00000420534
ENST00000465431
ENST00000496803
ENST00000460501
ENST00000553851 ENSP00000451962
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005083 small GTPase regulator activity
GO:0005515 protein binding
Biological Process
GO:0006914 autophagy
GO:0008219 cell death
GO:0050790 regulation of catalytic activity
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.613710 Hs.632807
RefSeq NM_001029896 NM_007075 NM_007213
HUGO
OMIM
CCDS CCDS14318 CCDS35250 CCDS14317
HPRD 06597
IMGT
EMBL
GenPept
RNA Seq Atlas