Version 5.4
Homo sapiens Gene: PAK1
Summary
InnateDB Gene IDBG-65610.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAK1
Gene Name p21 protein (Cdc42/Rac)-activated kinase 1
Synonyms PAKalpha
Species Homo sapiens
Ensembl Gene ENSG00000149269
Encoded Proteins
IDBP-65612
p21 protein (Cdc42/Rac)-activated kinase 1
IDBP-65614
p21 protein (Cdc42/Rac)-activated kinase 1
IDBP-587815
p21 protein (Cdc42/Rac)-activated kinase 1
IDBP-586489
p21 protein (Cdc42/Rac)-activated kinase 1
IDBP-585819
p21 protein (Cdc42/Rac)-activated kinase 1
IDBP-601010
p21 protein (Cdc42/Rac)-activated kinase 1
IDBP-592675
p21 protein (Cdc42/Rac)-activated kinase 1
IDBP-585767
p21 protein (Cdc42/Rac)-activated kinase 1
IDBP-593019
p21 protein (Cdc42/Rac)-activated kinase 1
IDBP-584331
p21 protein (Cdc42/Rac)-activated kinase 1
IDBP-599939
p21 protein (Cdc42/Rac)-activated kinase 1
IDBP-584005
p21 protein (Cdc42/Rac)-activated kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:77321707-77474635
Strand Reverse strand
Band q14.1
Transcripts
ENST00000278568 ENSP00000278568
ENST00000356341 ENSP00000348696
ENST00000530617 ENSP00000433423
ENST00000528203 ENSP00000433211
ENST00000527457 ENSP00000431906
ENST00000525542
ENST00000533285 ENSP00000431541
ENST00000527535 ENSP00000437261
ENST00000532991
ENST00000532711
ENST00000530358
ENST00000526103
ENST00000533468
ENST00000533568
ENST00000526910
ENST00000529248 ENSP00000433518
ENST00000524847 ENSP00000432477
ENST00000528592 ENSP00000433004
ENST00000528633 ENSP00000435983
ENST00000526968 ENSP00000433737
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 161 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 161 [view]
Protein-Protein 160 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
Biological Process
GO:0001666 response to hypoxia
GO:0001934 positive regulation of protein phosphorylation
GO:0006468 protein phosphorylation
GO:0006887 exocytosis
GO:0006915 apoptotic process
GO:0007015 actin filament organization
GO:0007411 axon guidance
GO:0007528 neuromuscular junction development
GO:0010033 response to organic substance
GO:0016358 dendrite development
GO:0023014 signal transduction by phosphorylation
GO:0031295 T cell costimulation
GO:0031532 actin cytoskeleton reorganization
GO:0032869 cellular response to insulin stimulus
GO:0032956 regulation of actin cytoskeleton organization
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042060 wound healing
GO:0043113 receptor clustering
GO:0043507 positive regulation of JUN kinase activity
GO:0045087 innate immune response
GO:0046777 protein autophosphorylation
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048812 neuron projection morphogenesis
GO:0050852 T cell receptor signaling pathway
GO:0051496 positive regulation of stress fiber assembly
GO:0060244 negative regulation of cell proliferation involved in contact inhibition
Cellular Component
GO:0001726 ruffle
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0014704 intercalated disc
GO:0016020 membrane
GO:0030018 Z disc
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0031941 filamentous actin
GO:0031965 nuclear membrane
GO:0032587 ruffle membrane
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030774
View Gene Order
ENSBTAG00000010191
Not yet available
Pathways
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
NetPath_9
TNFalpha pathway
NetPath_11
TCR pathway
NetPath_15
IL3 pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_12623
Generation of second messenger molecules pathway
REACT_19238
CD28 dependent Vav1 pathway pathway
REACT_19183
CD28 co-stimulation pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_25299
DSCAM interactions pathway
REACT_22272
Signal transduction by L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_19236
Sema3A PAK dependent Axon repulsion pathway
REACT_19226
Activation of Rac pathway
REACT_19351
Signaling by Robo receptor pathway
REACT_111045
Developmental Biology pathway
REACT_111155
Cell-Cell communication pathway
REACT_12526
TCR signaling pathway
REACT_19271
Semaphorin interactions pathway
REACT_228085
EPHB-mediated forward signaling pathway
REACT_12529
Signaling by VEGF pathway
REACT_6802
Innate Immune System pathway
REACT_228016
VEGFR2 mediated vascular permeability pathway
REACT_18266
Axon guidance pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_228226
Ephrin signaling pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_163701
FCERI mediated MAPK activation pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa04012
ErbB signaling pathway pathway
hsa05211
Renal cell carcinoma pathway
hsa04010
MAPK signaling pathway pathway
hsa04360
Axon guidance pathway
hsa04510
Focal adhesion pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04062
Chemokine signaling pathway pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
PDGF signaling pathway pathway
PID NCI
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
aurora_a_pathway
Aurora A signaling
cxcr4_pathway
CXCR4-mediated signaling events
netrin_pathway
Netrin-mediated signaling events
s1p_s1p2_pathway
S1P2 pathway
fak_pathway
Signaling events mediated by focal adhesion kinase
ephbfwdpathway
EPHB forward signaling
rac1_pathway
RAC1 signaling pathway
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
cdc42_pathway
CDC42 signaling events
epha2_fwdpathway
EPHA2 forward signaling
pdgfrbpathway
PDGFR-beta signaling pathway
plk1_pathway
PLK1 signaling events
Cross-References
SwissProt
TrEMBL E9PJF8 E9PMP2 E9PRP6
UniProt Splice Variant
Entrez Gene 5058
UniGene Hs.435714 Hs.734476
RefSeq NM_001128620 NM_002576 XM_005274025 XM_006718572 XM_006718573 XM_006718574 XM_006718575 XM_006718576
HUGO HGNC:8590
OMIM 602590
CCDS CCDS44687 CCDS8250
HPRD 03995
IMGT
EMBL AP000486 AP003680
GenPept
RNA Seq Atlas 5058

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca