Homo sapiens Gene: PAK1
Summary
InnateDB Gene IDBG-65610.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAK1
Gene Name p21 protein (Cdc42/Rac)-activated kinase 1
Synonyms PAKalpha;
Species Homo sapiens
Ensembl Gene ENSG00000149269
Encoded Proteins
p21 protein (Cdc42/Rac)-activated kinase 1
p21 protein (Cdc42/Rac)-activated kinase 1
p21 protein (Cdc42/Rac)-activated kinase 1
p21 protein (Cdc42/Rac)-activated kinase 1
p21 protein (Cdc42/Rac)-activated kinase 1
p21 protein (Cdc42/Rac)-activated kinase 1
p21 protein (Cdc42/Rac)-activated kinase 1
p21 protein (Cdc42/Rac)-activated kinase 1
p21 protein (Cdc42/Rac)-activated kinase 1
p21 protein (Cdc42/Rac)-activated kinase 1
p21 protein (Cdc42/Rac)-activated kinase 1
p21 protein (Cdc42/Rac)-activated kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:77321707-77474635
Strand Reverse strand
Band q14.1
Transcripts
ENST00000278568 ENSP00000278568
ENST00000356341 ENSP00000348696
ENST00000530617 ENSP00000433423
ENST00000528203 ENSP00000433211
ENST00000527457 ENSP00000431906
ENST00000525542
ENST00000533285 ENSP00000431541
ENST00000527535 ENSP00000437261
ENST00000532991
ENST00000532711
ENST00000530358
ENST00000526103
ENST00000533468
ENST00000533568
ENST00000526910
ENST00000529248 ENSP00000433518
ENST00000524847 ENSP00000432477
ENST00000528592 ENSP00000433004
ENST00000528633 ENSP00000435983
ENST00000526968 ENSP00000433737
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 161 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 161 [view]
Protein-Protein 160 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
Biological Process
GO:0001666 response to hypoxia
GO:0001934 positive regulation of protein phosphorylation
GO:0006468 protein phosphorylation
GO:0006887 exocytosis
GO:0006915 apoptotic process
GO:0007015 actin filament organization
GO:0007411 axon guidance
GO:0007528 neuromuscular junction development
GO:0010033 response to organic substance
GO:0016358 dendrite development
GO:0023014 signal transduction by phosphorylation
GO:0031295 T cell costimulation
GO:0031532 actin cytoskeleton reorganization
GO:0032869 cellular response to insulin stimulus
GO:0032956 regulation of actin cytoskeleton organization
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042060 wound healing
GO:0043113 receptor clustering
GO:0043507 positive regulation of JUN kinase activity
GO:0045087 innate immune response
GO:0046777 protein autophosphorylation
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048812 neuron projection morphogenesis
GO:0050852 T cell receptor signaling pathway
GO:0051496 positive regulation of stress fiber assembly
GO:0060244 negative regulation of cell proliferation involved in contact inhibition
Cellular Component
GO:0001726 ruffle
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0014704 intercalated disc
GO:0016020 membrane
GO:0030018 Z disc
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0031941 filamentous actin
GO:0031965 nuclear membrane
GO:0032587 ruffle membrane
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Alpha6Beta4Integrin pathway
EGFR1 pathway
KitReceptor pathway
TNFalpha pathway
TCR pathway
IL3 pathway
Prolactin pathway
REACTOME
Regulation of actin dynamics for phagocytic cup formation pathway
Developmental Biology pathway
Cell-Cell communication pathway
TCR signaling pathway
Semaphorin interactions pathway
EPHB-mediated forward signaling pathway
Signaling by VEGF pathway
Innate Immune System pathway
VEGFR2 mediated vascular permeability pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
Activation of Rac pathway
Signal Transduction pathway
CD28 co-stimulation pathway
CD28 dependent Vav1 pathway pathway
Sema3A PAK dependent Axon repulsion pathway
Adaptive Immune System pathway
Immune System pathway
Ephrin signaling pathway
VEGFA-VEGFR2 Pathway pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
L1CAM interactions pathway
Signal transduction by L1 pathway
DSCAM interactions pathway
EPH-Ephrin signaling pathway
Signaling by Robo receptor pathway
Generation of second messenger molecules pathway
Costimulation by the CD28 family pathway
FCERI mediated MAPK activation pathway
KEGG
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
Axon guidance pathway
Focal adhesion pathway
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Regulation of actin cytoskeleton pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
Renal cell carcinoma pathway
INOH
PDGF signaling pathway pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
Ras-independent pathway in nk cell-mediated cytotoxicity [Biocarta view]
Agrin in postsynaptic differentiation [Biocarta view]
Angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling [Biocarta view]
Fas signaling pathway (cd95) [Biocarta view]
Fmlp induced chemokine gene expression in hmc-1 cells [Biocarta view]
Rac1 cell motility signaling pathway [Biocarta view]
Role of pi3k subunit p85 in regulation of actin organization and cell migration [Biocarta view]
Mapkinase signaling pathway [Biocarta view]
Links between pyk2 and map kinases [Biocarta view]
Influence of ras and rho proteins on g1 to s transition [Biocarta view]
PID NCI
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Aurora A signaling
CXCR4-mediated signaling events
Netrin-mediated signaling events
S1P2 pathway
Signaling events mediated by focal adhesion kinase
EPHB forward signaling
RAC1 signaling pathway
Angiopoietin receptor Tie2-mediated signaling
CDC42 signaling events
EPHA2 forward signaling
PDGFR-beta signaling pathway
PLK1 signaling events
Cross-References
SwissProt
TrEMBL E9PJF8 E9PKH9 E9PMP2 E9PQW5 E9PRP6
UniProt Splice Variant
Entrez Gene 5058
UniGene Hs.435714 Hs.734476
RefSeq NM_001128620 NM_002576 XM_006718572 XM_006718573 XM_006718575 XM_006718576 XM_006718574 XM_005274025
HUGO HGNC:8590
OMIM 602590
CCDS CCDS44687 CCDS8250
HPRD 03995
IMGT
EMBL AP000486 AP003680
GenPept
RNA Seq Atlas 5058