Homo sapiens Gene: KPNA2
Summary
InnateDB Gene IDBG-65703.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KPNA2
Gene Name karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
Synonyms IPOA1; QIP2; RCH1; SRP1alpha;
Species Homo sapiens
Ensembl Gene ENSG00000182481
Encoded Proteins
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:68035519-68046842
Strand Forward strand
Band q24.2
Transcripts
ENST00000330459 ENSP00000332455
ENST00000537025 ENSP00000438483
ENST00000583392
ENST00000584026 ENSP00000463602
ENST00000579754 ENSP00000462331
ENST00000583269 ENSP00000463320
ENST00000582898
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 174 experimentally validated interaction(s) in this database.
Experimentally validated
Total 174 [view]
Protein-Protein 174 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008139 nuclear localization sequence binding
GO:0008565 protein transporter activity
GO:0042826 histone deacetylase binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000018 regulation of DNA recombination
GO:0000085 mitotic G2 phase
GO:0006259 DNA metabolic process
GO:0006606 protein import into nucleus
GO:0006607 NLS-bearing protein import into nucleus
GO:0016032 viral process
GO:0019221 cytokine-mediated signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
TNFalpha pathway
REACTOME
Antiviral mechanism by IFN-stimulated genes pathway
Cytokine Signaling in Immune system pathway
Interferon Signaling pathway
Immune System pathway
ISG15 antiviral mechanism pathway
KEGG
INOH
PID BIOCARTA
Role of ran in mitotic spindle regulation [Biocarta view]
Mechanism of protein import into the nucleus [Biocarta view]
PID NCI
Signaling events mediated by TCPTP
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
Cross-References
SwissProt
TrEMBL J3QL07
UniProt Splice Variant
Entrez Gene 3838
UniGene Hs.594238
RefSeq NM_002266
HUGO HGNC:6395
OMIM 600685
CCDS CCDS32713
HPRD 02818
IMGT
EMBL AC134407
GenPept
RNA Seq Atlas 3838