InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KPNA2

Summary

InnateDB Gene

IDBG-65703.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KPNA2

Gene Name

karyopherin alpha 2 (RAG cohort 1, importin alpha 1)

Synonyms

IPOA1; QIP2; RCH1; SRP1alpha

Species

Homo sapiens

Ensembl Gene

ENSG00000182481

Encoded Proteins

IDBP-65705

karyopherin alpha 2 (RAG cohort 1, importin alpha 1)

IDBP-590144

karyopherin alpha 2 (RAG cohort 1, importin alpha 1)

IDBP-763144

IDBP-759033

IDBP-759521

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:68035519-68046842

Strand

Forward strand

Band

q24.2

Transcripts

ENST00000330459	ENSP00000332455
ENST00000537025	ENSP00000438483
ENST00000583392
ENST00000584026	ENSP00000463602
ENST00000579754	ENSP00000462331
ENST00000583269	ENSP00000463320
ENST00000582898

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 174 experimentally validated interaction(s) in this database.

Experimentally validated
Total	174 [view]
Protein-Protein	174 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008139	nuclear localization sequence binding
GO:0008565	protein transporter activity
GO:0042826	histone deacetylase binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000018	regulation of DNA recombination
GO:0000085	mitotic G2 phase
GO:0006259	DNA metabolic process
GO:0006606	protein import into nucleus
GO:0006607	NLS-bearing protein import into nucleus
GO:0016032	viral process
GO:0019221	cytokine-mediated signaling pathway