Homo sapiens Gene: ARSG
Summary
InnateDB Gene IDBG-65797.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARSG
Gene Name arylsulfatase G
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000141337
Encoded Proteins
arylsulfatase G
arylsulfatase G
arylsulfatase G
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the sulfatase enzyme family. Sulfatases hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules. This protein displays arylsulfatase activity at acidic pH, as is typical of lysosomal sulfatases, and has been shown to localize in the lysosomes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:68259182-68422731
Strand Forward strand
Band q24.2
Transcripts
ENST00000452479 ENSP00000413953
ENST00000448504 ENSP00000407193
ENST00000582154
ENST00000581032
ENST00000590690
ENST00000578554
ENST00000581639 ENSP00000462306
ENST00000578726
ENST00000621439 ENSP00000480910
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004065 arylsulfatase activity
GO:0008484 sulfuric ester hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006665 sphingolipid metabolic process
GO:0006687 glycosphingolipid metabolic process
GO:0006790 sulfur compound metabolic process
GO:0008152 metabolic process
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Sphingolipid metabolism pathway
Metabolism of lipids and lipoproteins pathway
Post-translational protein modification pathway
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
Metabolism of proteins pathway
The activation of arylsulfatases pathway
Glycosphingolipid metabolism pathway
Metabolism pathway
KEGG
Lysosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001267727 NM_014960 XM_005257172 XM_006721776 XM_006721777 XM_006721778 XM_006721779 XM_006721780
HUGO
OMIM
CCDS CCDS11676
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas