Version 5.4
Homo sapiens Gene: SVIL
Summary
InnateDB Gene IDBG-66231.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SVIL
Gene Name supervillin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000197321
Encoded Proteins
IDBP-66235
supervillin
IDBP-66237
supervillin
IDBP-66239
supervillin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Two transcript variants encoding different isoforms of supervillin have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:29457338-29736781
Strand Reverse strand
Band p11.23
Transcripts
ENST00000375400 ENSP00000364549
ENST00000375398 ENSP00000364547
ENST00000355867 ENSP00000348128
ENST00000460007
ENST00000482607
ENST00000474106
ENST00000491872
ENST00000464984
ENST00000483758
ENST00000464726
ENST00000490031
ENST00000465422
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
Experimentally validated
Total 72 [view]
Protein-Protein 72 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0051015 actin filament binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0007519 skeletal muscle tissue development
Cellular Component
GO:0002102 podosome
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0015629 actin cytoskeleton
GO:0030054 cell junction
GO:0043034 costamere
GO:0071437 invadopodium
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000024236
View Gene Order
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
KEGG
INOH
PID NCI
ar_pathway
Coregulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.499209
RefSeq NM_003174 NM_021738 XM_005252567 XM_005252569 XM_006717496
HUGO
OMIM
CCDS CCDS7163 CCDS7164
HPRD 04992
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca