Homo sapiens Protein: SVIL | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-66235.7 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | SVIL | ||||||||||||||||||
Protein Name | supervillin | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000364549 | ||||||||||||||||||
InnateDB Gene | IDBG-66231 (SVIL) | ||||||||||||||||||
Protein Structure |
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UniProt Annotation | |||||||||||||||||||
Function | Forms a high-affinity link between the actin cytoskeleton and the membrane. Isoform 1 (archvillin) is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function. Isoform 2 may be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6 (By similarity). {ECO:0000250}. | ||||||||||||||||||
Subcellular Localization | Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, invadopodium. Cell projection, podosome. Note=Tightly associated with both actin filaments and plasma membranes. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Expressed in many tissues. Most abundant in muscle, bone marrow, thyroid gland and salivary gland. Isoform 1 (archvillin) is muscle specific. {ECO:0000269PubMed:9867483}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR003128
Villin headpiece IPR007122 Villin/Gelsolin IPR007123 Gelsolin-like domain |
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PFAM |
PF02209
PF00626 |
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PRINTS |
PR00597
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PIRSF | |||||||||||||||||||
SMART |
SM00153
SM00262 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | O95425 | ||||||||||||||||||
PhosphoSite | PhosphoSite-O95425 | ||||||||||||||||||
TrEMBL | Q569J5 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 6840 | ||||||||||||||||||
UniGene | Hs.499209 | ||||||||||||||||||
RefSeq | NP_003165 | ||||||||||||||||||
HUGO | HGNC:11480 | ||||||||||||||||||
OMIM | 604126 | ||||||||||||||||||
CCDS | CCDS7163 | ||||||||||||||||||
HPRD | 04992 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AF051850 AF051851 AF109135 AL158167 AL160060 BC092440 CH471072 JX467682 | ||||||||||||||||||
GenPept | AAC64695 AAC64696 AAD14682 AAH92440 AGE81989 CAH71300 CAH71301 CAI15236 CAI15237 EAW86018 EAW86019 | ||||||||||||||||||