InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SVIL

Summary

InnateDB Protein

IDBP-66235.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SVIL

Protein Name

supervillin

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000364549

InnateDB Gene

IDBG-66231 (SVIL)

Protein Structure

UniProt Annotation

Function

Forms a high-affinity link between the actin cytoskeleton and the membrane. Isoform 1 (archvillin) is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function. Isoform 2 may be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6 (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, invadopodium. Cell projection, podosome. Note=Tightly associated with both actin filaments and plasma membranes.

Disease Associations

Tissue Specificity

Expressed in many tissues. Most abundant in muscle, bone marrow, thyroid gland and salivary gland. Isoform 1 (archvillin) is muscle specific. {ECO:0000269PubMed:9867483}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.

Experimentally validated
Total	72 [view]
Protein-Protein	72 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0051015	actin filament binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0007519	skeletal muscle tissue development

Cellular Component

GO:0002102	podosome
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0015629	actin cytoskeleton
GO:0030054	cell junction
GO:0043034	costamere
GO:0071437	invadopodium