Homo sapiens Gene: HIST1H2BA
Summary
InnateDB Gene IDBG-66290.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIST1H2BA
Gene Name histone cluster 1, H2ba
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000146047
Encoded Proteins
histone cluster 1, H2ba
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:25726909-25727292
Strand Forward strand
Band p22.2
Transcripts
ENST00000274764 ENSP00000274764
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006337 nucleosome disassembly
GO:0006954 inflammatory response
GO:0031639 plasminogen activation
GO:0035093 spermatogenesis, exchange of chromosomal proteins
GO:0051099 positive regulation of binding
GO:0071229 cellular response to acid
GO:0071674 mononuclear cell migration
Cellular Component
GO:0000786 nucleosome
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0019897 extrinsic component of plasma membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
HATs acetylate histones pathway
Cellular responses to stress pathway
Packaging Of Telomere Ends pathway
PRC2 methylates histones and DNA pathway
Deposition of new CENPA-containing nucleosomes at the centromere pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
RNA Polymerase I Transcription pathway
Signaling by WNT in cancer pathway
Condensation of Prophase Chromosomes pathway
Signaling by Wnt pathway
Meiotic synapsis pathway
Chromosome Maintenance pathway
Nucleosome assembly pathway
Transcriptional regulation by small RNAs pathway
Epigenetic regulation of gene expression pathway
RNA Polymerase I Promoter Clearance pathway
NoRC negatively regulates rRNA expression pathway
Telomere Maintenance pathway
Signal Transduction pathway
SIRT1 negatively regulates rRNA Expression pathway
Amyloids pathway
Cell Cycle pathway
DNA Damage/Telomere Stress Induced Senescence pathway
HDACs deacetylate histones pathway
DNA methylation pathway
M Phase pathway
Cellular Senescence pathway
TCF dependent signaling in response to WNT pathway
Meiotic recombination pathway
Chromatin organization pathway
RNA Polymerase I Promoter Opening pathway
RNA Polymerase I Chain Elongation pathway
Mitotic Prophase pathway
Chromatin modifying enzymes pathway
Cell Cycle, Mitotic pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
formation of the beta-catenin:TCF transactivating complex pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Meiosis pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Oxidative Stress Induced Senescence pathway
Gene Expression pathway
Disease pathway
Negative epigenetic regulation of rRNA expression pathway
Regulatory RNA pathways pathway
KEGG
Systemic lupus erythematosus pathway
INOH
PID BIOCARTA
PID NCI
FOXM1 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.624410
RefSeq NM_170610
HUGO
OMIM
CCDS CCDS4563
HPRD 11024
IMGT
EMBL
GenPept
RNA Seq Atlas