Homo sapiens Gene: FPR2
Summary
InnateDB Gene IDBG-66320.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FPR2
Gene Name formyl peptide receptor 2
Synonyms ALXR; FMLP-R-II; FMLPX; FPR2A; FPRH1; FPRH2; FPRL1; HM63; LXA4R;
Species Homo sapiens
Ensembl Gene ENSG00000171049
Encoded Proteins
formyl peptide receptor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
FPR1 and FPR2 are G-protein-coupled receptors that recognize bacterial signal peptides, constituting a novel class of immune activators that contribute to mammalian immune defence against bacteria.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:51752026-51770526
Strand Forward strand
Band q13.41
Transcripts
ENST00000340023 ENSP00000340191
ENST00000600258 ENSP00000470373
ENST00000598953 ENSP00000468876
ENST00000598776 ENSP00000468897
ENST00000599326 ENSP00000469085
ENST00000600722 ENSP00000472259
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004982 N-formyl peptide receptor activity
Biological Process
GO:0006928 cellular component movement
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0007155 cell adhesion
GO:0007186 G-protein coupled receptor signaling pathway
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Class A/1 (Rhodopsin-like receptors) pathway
G alpha (q) signalling events pathway
Formyl peptide receptors bind formyl peptides and many other ligands pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
GPCR ligand binding pathway
KEGG
Neuroactive ligand-receptor interaction pathway
Staphylococcus aureus infection pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL M0QZ89
UniProt Splice Variant
Entrez Gene 2358
UniGene Hs.99855
RefSeq NM_001005738 NM_001462
HUGO HGNC:3827
OMIM 136538
CCDS CCDS12840
HPRD 00647
IMGT
EMBL AC018755
GenPept
RNA Seq Atlas 2358