InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FPR2

Summary

InnateDB Protein

IDBP-66322.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FPR2

Protein Name

formyl peptide receptor 2

Synonyms

ALXR; FMLP-R-II; FMLPX; FPR2A; FPRH1; FPRH2; FPRL1; HM63; LXA4R;

Species

Homo sapiens

Ensembl Protein

ENSP00000340191

InnateDB Gene

IDBG-66320 (FPR2)

Protein Structure

UniProt Annotation

Function

Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4).

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis. {ECO:0000269PubMed:9151906}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004982	N-formyl peptide receptor activity

Biological Process

GO:0006928	cellular component movement
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0007155	cell adhesion
GO:0007186	G-protein coupled receptor signaling pathway
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR002234 Anaphylatoxin chemotactic receptor family
IPR002258 DEZ orphan receptor
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR01104
PR01126

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P25090