InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SSTR2

Summary

InnateDB Gene

IDBG-66695.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SSTR2

Gene Name

somatostatin receptor 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000180616

Encoded Proteins

IDBP-66697

somatostatin receptor 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:73165012-73176633

Strand

Forward strand

Band

q25.1

Transcripts

ENST00000357585	ENSP00000350198
ENST00000579323

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004994	somatostatin receptor activity
GO:0005515	protein binding
GO:0030165	PDZ domain binding

Biological Process

GO:0006937	regulation of muscle contraction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007267	cell-cell signaling
GO:0007283	spermatogenesis
GO:0007584	response to nutrient
GO:0007586	digestion
GO:0008285	negative regulation of cell proliferation
GO:0021549	cerebellum development
GO:0030432	peristalsis
GO:0030900	forebrain development
GO:0042594	response to starvation
GO:0071385	cellular response to glucocorticoid stimulus
GO:0071392	cellular response to estradiol stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

Method

Confidence

Comments

ENSMUSG00000047904

View Gene Order

Ortholuge

SSD Ortholog

Ortholog supports species divergence

ENSBTAG00000017136

Not yet available

Ortholuge

SSD Ortholog

Ortholog supports species divergence

Pathways

NETPATH

REACTOME

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_14819

Peptide ligand-binding receptors pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_19231

G alpha (i) signalling events pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

hsa04971

Gastric acid secretion pathway

INOH

PID BIOCARTA

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.514451

RefSeq

NM_001050

HUGO

OMIM

CCDS

CCDS11691

HPRD

01674

IMGT

EMBL

GenPept

RNA Seq Atlas