InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sstr2

Summary

InnateDB Gene

IDBG-214022.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sstr2

Gene Name

somatostatin receptor 2

Synonyms

Smstr-2; Smstr2; sst2; SSTR-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000047904

Encoded Proteins

IDBP-214024

somatostatin receptor 2

IDBP-268380

somatostatin receptor 2

IDBP-789518

somatostatin receptor 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000180616:
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:113619342-113626028

Strand

Forward strand

Band

Transcripts

ENSMUST00000067591	ENSMUSP00000068578
ENSMUST00000106630	ENSMUSP00000102241
ENSMUST00000146390	ENSMUSP00000138101

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004994	somatostatin receptor activity
GO:0005515	protein binding
GO:0030165	PDZ domain binding

Biological Process

GO:0006937	regulation of muscle contraction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007283	spermatogenesis
GO:0021549	cerebellum development
GO:0030432	peristalsis
GO:0030900	forebrain development
GO:0038170	somatostatin signaling pathway
GO:0042594	response to starvation
GO:0071385	cellular response to glucocorticoid stimulus
GO:0071392	cellular response to estradiol stimulus