Version 5.4
Homo sapiens Gene: IL36B
Summary
InnateDB Gene IDBG-66719.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL36B
Gene Name interleukin 36, beta
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000136696
Encoded Proteins
IDBP-66721
interleukin 36, beta
IDBP-66723
interleukin 36, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:113022091-113052867
Strand Reverse strand
Band q14.1
Transcripts
ENST00000259213 ENSP00000259213
ENST00000327407 ENSP00000328420
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005149 interleukin-1 receptor binding
Biological Process
GO:0001819 positive regulation of cytokine production
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0032755 positive regulation of interleukin-6 production
GO:0045582 positive regulation of T cell differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q9NZH7
TrEMBL
UniProt Splice Variant
Entrez Gene 27177
UniGene Hs.278909
RefSeq NM_014438 NM_173178
HUGO HGNC:15564
OMIM 605508
CCDS CCDS2109 CCDS2110
HPRD 05694
IMGT
EMBL AC016724 AF200494 AF201833 BC101831 BC101833 BN000002 CH471217 DQ224343
GenPept AAF25213 AAF69250 AAI01832 AAI01834 AAY14989 ABA60896 CAD29876 EAW73615
RNA Seq Atlas 27177

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca