Homo sapiens Gene: HIST1H1A
Summary
InnateDB Gene IDBG-66749.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIST1H1A
Gene Name histone cluster 1, H1a
Synonyms H1.1; H1A; H1F1; HIST1;
Species Homo sapiens
Ensembl Gene ENSG00000124610
Encoded Proteins
histone cluster 1, H1a
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:26017085-26017732
Strand Reverse strand
Band p22.2
Transcripts
ENST00000244573 ENSP00000244573
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
Experimentally validated
Total 75 [view]
Protein-Protein 75 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0031490 chromatin DNA binding
Biological Process
GO:0006334 nucleosome assembly
GO:0007283 spermatogenesis
Cellular Component
GO:0000786 nucleosome
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005719 nuclear euchromatin
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Apoptotic execution phase pathway
Cellular responses to stress pathway
Apoptosis induced DNA fragmentation pathway
Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway
Activation of DNA fragmentation factor pathway
Apoptosis pathway
DNA Damage/Telomere Stress Induced Senescence pathway
Cellular Senescence pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q02539
TrEMBL
UniProt Splice Variant
Entrez Gene 3024
UniGene Hs.150206
RefSeq NM_005325
HUGO HGNC:4715
OMIM 142709
CCDS CCDS4569
HPRD 00820
IMGT
EMBL AF531299 BC069492 BC101593 BC112140 U91328 X57130
GenPept AAH69492 AAI01594 AAI12141 AAN06699 CAA40409
RNA Seq Atlas 3024