InnateDB Protein
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IDBP-66751.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HIST1H1A
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Protein Name
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histone cluster 1, H1a
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Synonyms
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H1.1; H1A; H1F1; HIST1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000244573
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InnateDB Gene
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IDBG-66749 (HIST1H1A)
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Protein Structure
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Function |
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00837, ECO:0000269PubMed:15911621}. Chromosome {ECO:0000255PROSITE-ProRule:PRU00837, ECO:0000269PubMed:15911621}. Note=Mainly localizes in euchromatin.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
75
[view]
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Protein-Protein |
75
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005818
Linker histone H1/H5, domain H15
IPR005819
Histone H5
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PFAM |
PF00538
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PRINTS |
PR00624
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PIRSF |
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SMART |
SM00526
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TIGRFAMs |
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Modification |
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SwissProt |
Q02539
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PhosphoSite |
PhosphoSite-Q02539
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
3024
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UniGene |
Hs.150206
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RefSeq |
NP_005316
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HUGO |
HGNC:4715
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OMIM |
142709
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CCDS |
CCDS4569
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HPRD |
00820
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IMGT |
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EMBL |
AF531299
BC069492
BC101593
BC112140
U91328
X57130
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GenPept |
AAH69492
AAI01594
AAI12141
AAN06699
CAA40409
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