InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PTGDR

Summary

InnateDB Gene

IDBG-6705.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTGDR

Gene Name

prostaglandin D2 receptor (DP)

Synonyms

AS1; ASRT1; DP; DP1; PTGDR1

Species

Homo sapiens

Ensembl Gene

ENSG00000168229

Encoded Proteins

IDBP-6707

prostaglandin D2 receptor (DP)

IDBP-590687

prostaglandin D2 receptor (DP)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a G-protein-coupled receptor. It has been shown to function as a prostanoid DP receptor. The activity of this receptor is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+. Knockout studies in mice suggest that the ligand of this receptor, prostaglandin D2 (PGD2), functions as a mast cell-derived mediator to trigger asthmatic responses. [provided by RefSeq, Jul 2008]
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein is reported to be a receptor for prostaglandin D2, which is a mediator of allergic inflammation and allergic airway inflammation in asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:52267713-52276724

Strand

Forward strand

Band

q22.1

Transcripts

ENST00000306051	ENSP00000303424
ENST00000553372	ENSP00000452408

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001785	prostaglandin J receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004956	prostaglandin D receptor activity
GO:0005515	protein binding

Biological Process

GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0030238	male sex determination
GO:0030431	sleep
GO:0046085	adenosine metabolic process
GO:0071799	cellular response to prostaglandin D stimulus