InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTGDR

Summary

InnateDB Protein

IDBP-6707.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTGDR

Protein Name

prostaglandin D2 receptor (DP)

Synonyms

AS1; ASRT1; DP; DP1; PTGDR1;

Species

Homo sapiens

Ensembl Protein

ENSP00000303424

InnateDB Gene

IDBG-6705 (PTGDR)

Protein Structure

UniProt Annotation

Function

Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Asthma-related traits 1 (ASRT1) [MIM:607277]: Asthma- related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. {ECO:0000269PubMed:15496624}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Expressed in retinal choroid, ciliary epithelium, longitudinal and circular ciliary muscles, iris, small intestine and platelet membranes. {ECO:0000269PubMed:11082108, ECO:0000269PubMed:6302737}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001785	prostaglandin J receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004956	prostaglandin D receptor activity
GO:0005515	protein binding

Biological Process

GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0030238	male sex determination
GO:0030431	sleep
GO:0046085	adenosine metabolic process
GO:0071799	cellular response to prostaglandin D stimulus

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000376 Prostaglandin D receptor
IPR008365 Prostanoid receptor
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR00854
PR01788

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q13258