Homo sapiens Gene: HIST1H1C
Summary
InnateDB Gene IDBG-67352.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIST1H1C
Gene Name histone cluster 1, H1c
Synonyms H1.2; H1C; H1F2; H1s-1;
Species Homo sapiens
Ensembl Gene ENSG00000187837
Encoded Proteins
histone cluster 1, H1c
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:26055787-26056428
Strand Reverse strand
Band p22.2
Transcripts
ENST00000343677 ENSP00000339566
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 103 experimentally validated interaction(s) in this database.
Experimentally validated
Total 103 [view]
Protein-Protein 102 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0031490 chromatin DNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006334 nucleosome assembly
GO:0016584 nucleosome positioning
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005719 nuclear euchromatin
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Apoptotic execution phase pathway
Cellular responses to stress pathway
Apoptosis induced DNA fragmentation pathway
Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway
Activation of DNA fragmentation factor pathway
Apoptosis pathway
DNA Damage/Telomere Stress Induced Senescence pathway
Cellular Senescence pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P16403
TrEMBL
UniProt Splice Variant
Entrez Gene 3006
UniGene
RefSeq NM_005319
HUGO HGNC:4716
OMIM 142710
CCDS CCDS4577
HPRD 07514
IMGT
EMBL AB451259 AB451385 AF531300 AK290947 BC002649 CH471087 U91328 X57129
GenPept AAN06700 BAF83636 BAG70073 BAG70199 CAA40408 EAW55515
RNA Seq Atlas 3006