Version 5.4
Homo sapiens Protein: HIST1H1C
Summary
InnateDB Protein IDBP-67354.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIST1H1C
Protein Name histone cluster 1, H1c
Synonyms H1.2; H1C; H1F2; H1s-1;
Species Homo sapiens
Ensembl Protein ENSP00000339566
InnateDB Gene IDBG-67352 (HIST1H1C)
Protein Structure
UniProt Annotation
Function Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus. Chromosome. Note=Mainly localizes in euchromatin. Distribution goes in parallel with DNA concentration.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 103 experimentally validated interaction(s) in this database.
Experimentally validated
Total 103 [view]
Protein-Protein 102 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0031490 chromatin DNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006334 nucleosome assembly
GO:0016584 nucleosome positioning
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005719 nuclear euchromatin
Protein Structure and Domains
PDB ID
InterPro IPR005818 Linker histone H1/H5, domain H15
IPR005819 Histone H5
PFAM PF00538
PRINTS PR00624
PIRSF
SMART SM00526
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P16403
PhosphoSite PhosphoSite-P16403
TrEMBL
UniProt Splice Variant
Entrez Gene 3006
UniGene
RefSeq NP_005310
HUGO HGNC:4716
OMIM 142710
CCDS CCDS4577
HPRD 07514
IMGT
EMBL AB451259 AB451385 AF531300 AK290947 BC002649 CH471087 U91328 X57129
GenPept AAN06700 BAF83636 BAG70073 BAG70199 CAA40408 EAW55515

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca