Version 5.4
Homo sapiens Gene: PTGER2
Summary
InnateDB Gene IDBG-6740.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTGER2
Gene Name prostaglandin E receptor 2 (subtype EP2), 53kDa
Synonyms EP2
Species Homo sapiens
Ensembl Gene ENSG00000125384
Encoded Proteins
IDBP-6742
prostaglandin E receptor 2 (subtype EP2), 53kDa
IDBP-600605
prostaglandin E receptor 2 (subtype EP2), 53kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:52314305-52328606
Strand Forward strand
Band q22.1
Transcripts
ENST00000245457 ENSP00000245457
ENST00000557436 ENSP00000450933
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004957 prostaglandin E receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0032496 response to lipopolysaccharide
GO:0042127 regulation of cell proliferation
GO:0071380 cellular response to prostaglandin E stimulus
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037759
View Gene Order
ENSBTAG00000002163
Not yet available
Pathways
NETPATH
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_18425
Prostanoid ligand receptors pathway
REACT_18352
Eicosanoid ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL G3V2Y6
UniProt Splice Variant
Entrez Gene 5732
UniGene Hs.2090
RefSeq NM_000956
HUGO HGNC:9594
OMIM 176804
CCDS CCDS9708
HPRD 08905
IMGT
EMBL AL365475
GenPept
RNA Seq Atlas 5732

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca