Homo sapiens Gene: PTGER2
Summary
InnateDB Gene IDBG-6740.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTGER2
Gene Name prostaglandin E receptor 2 (subtype EP2), 53kDa
Synonyms EP2;
Species Homo sapiens
Ensembl Gene ENSG00000125384
Encoded Proteins
prostaglandin E receptor 2 (subtype EP2), 53kDa
prostaglandin E receptor 2 (subtype EP2), 53kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:52314305-52328606
Strand Forward strand
Band q22.1
Transcripts
ENST00000245457 ENSP00000245457
ENST00000557436 ENSP00000450933
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004957 prostaglandin E receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0032496 response to lipopolysaccharide
GO:0042127 regulation of cell proliferation
GO:0071380 cellular response to prostaglandin E stimulus
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
Eicosanoid ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
Prostanoid ligand receptors pathway
KEGG
Neuroactive ligand-receptor interaction pathway
INOH
PID BIOCARTA
Eicosanoid metabolism [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.2090
RefSeq NM_000956
HUGO
OMIM
CCDS CCDS9708
HPRD 08905
IMGT
EMBL
GenPept
RNA Seq Atlas