Homo sapiens Protein: PTGER2
Summary
InnateDB Protein IDBP-6742.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTGER2
Protein Name prostaglandin E receptor 2 (subtype EP2), 53kDa
Synonyms EP2;
Species Homo sapiens
Ensembl Protein ENSP00000245457
InnateDB Gene IDBG-6740 (PTGER2)
Protein Structure
UniProt Annotation
Function Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Placenta and lung.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004957 prostaglandin E receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0032496 response to lipopolysaccharide
GO:0042127 regulation of cell proliferation
GO:0071380 cellular response to prostaglandin E stimulus
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001923 Prostanoid EP2 receptor
IPR008365 Prostanoid receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)
PFAM PF00001
PF10320
PF10328
PRINTS PR00237
PR00581
PR01788
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P43116
PhosphoSite PhosphoSite-P43116
TrEMBL G3V2Y6
UniProt Splice Variant
Entrez Gene 5732
UniGene Hs.2090
RefSeq NP_000947
HUGO HGNC:9594
OMIM 176804
CCDS CCDS9708
HPRD 08905
IMGT
EMBL AF134201 AF134202 AL365475 AY275471 BC093927 BC093929 CH471078 DQ398948 U19487 X83868
GenPept AAA61681 AAD44177 AAH93927 AAH93929 AAP32303 ABD48958 CAA58749 EAW65652 EAW65654