Homo sapiens Gene: GRIN2C
Summary
InnateDB Gene IDBG-67631.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRIN2C
Gene Name glutamate receptor, ionotropic, N-methyl D-aspartate 2C
Synonyms GluN2C; NMDAR2C; NR2C;
Species Homo sapiens
Ensembl Gene ENSG00000161509
Encoded Proteins
glutamate receptor, ionotropic, N-methyl D-aspartate 2C
glutamate receptor, ionotropic, N-methyl D-aspartate 2C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq, Mar 2010]
This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson\'s disease, Alzheimer\'s disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:74842023-74861504
Strand Reverse strand
Band q25.1
Transcripts
ENST00000347612 ENSP00000338645
ENST00000293190 ENSP00000293190
ENST00000578159
ENST00000584176
ENST00000584496
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004970 ionotropic glutamate receptor activity
GO:0004972 N-methyl-D-aspartate selective glutamate receptor activity
GO:0005215 transporter activity
GO:0005234 extracellular-glutamate-gated ion channel activity
GO:0005261 cation channel activity
GO:0005515 protein binding
GO:0030165 PDZ domain binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0006810 transport
GO:0006812 cation transport
GO:0007215 glutamate receptor signaling pathway
GO:0007268 synaptic transmission
GO:0008104 protein localization
GO:0009611 response to wounding
GO:0033058 directional locomotion
GO:0034220 ion transmembrane transport
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035249 synaptic transmission, glutamatergic
GO:0042177 negative regulation of protein catabolic process
GO:0042391 regulation of membrane potential
GO:0050885 neuromuscular process controlling balance
GO:0060079 regulation of excitatory postsynaptic membrane potential
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0017146 N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054 cell junction
GO:0030425 dendrite
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Neuronal System pathway
Unblocking of NMDA receptor, glutamate binding and activation pathway
Post NMDA receptor activation events pathway
Ras activation uopn Ca2+ infux through NMDA receptor pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
CREB phosphorylation through the activation of Ras pathway
Transmission across Chemical Synapses pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
CREB phosphorylation through the activation of CaMKII pathway
KEGG
Calcium signaling pathway pathway
Neuroactive ligand-receptor interaction pathway
Long-term potentiation pathway
Alzheimer's disease pathway
Amyotrophic lateral sclerosis (ALS) pathway
INOH
GPCR Dopamine D1like receptor signaling pathway pathway
PID BIOCARTA
Nitric oxide signaling pathway [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.436980
RefSeq NM_000835 NM_001278553 XM_006721845 XM_006721846 XM_006721847
HUGO
OMIM
CCDS CCDS32724 CCDS62330
HPRD 00699
IMGT
EMBL
GenPept
RNA Seq Atlas