Homo sapiens Gene: EN1
Summary
InnateDB Gene IDBG-67827.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EN1
Gene Name engrailed homeobox 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163064
Encoded Proteins
engrailed homeobox 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]
Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the \'engrailed\' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:118842171-118847678
Strand Reverse strand
Band q14.2
Transcripts
ENST00000295206 ENSP00000295206
ENST00000546667
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001501 skeletal system development
GO:0009653 anatomical structure morphogenesis
GO:0009953 dorsal/ventral pattern formation
GO:0009954 proximal/distal pattern formation
GO:0010468 regulation of gene expression
GO:0030182 neuron differentiation
GO:0030326 embryonic limb morphogenesis
GO:0030901 midbrain development
GO:0030902 hindbrain development
GO:0030917 midbrain-hindbrain boundary development
GO:0035115 embryonic forelimb morphogenesis
GO:0035264 multicellular organism growth
GO:0042220 response to cocaine
GO:0043473 pigmentation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048666 neuron development
GO:0060173 limb development
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.271977 Hs.604307
RefSeq NM_001426
HUGO
OMIM
CCDS CCDS2123
HPRD 08835
IMGT
EMBL
GenPept
RNA Seq Atlas