Homo sapiens Gene: PRKCG
InnateDB Gene IDBG-67841.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRKCG
Gene Name protein kinase C, gamma
Synonyms PKC-gamma; PKCC; PKCG; SCA14
Species Homo sapiens
Ensembl Gene ENSG00000126583
Encoded Proteins
protein kinase C, gamma
protein kinase C, gamma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:53879190-53907652
Strand Forward strand
Band q13.42
ENST00000263431 ENSP00000263431
ENST00000419486 ENSP00000387919
ENST00000479081 ENSP00000471544
ENST00000474397 ENSP00000471271
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 41 [view]
Protein-DNA 0
Protein-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004697 protein kinase C activity
GO:0004698 calcium-dependent protein kinase C activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0006950 response to stress
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007268 synaptic transmission
GO:0007596 blood coagulation
GO:0007611 learning or memory
GO:0007635 chemosensory behavior
GO:0008219 cell death
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0016310 phosphorylation
GO:0030168 platelet activation
GO:0031397 negative regulation of protein ubiquitination
GO:0032425 positive regulation of mismatch repair
GO:0035556 intracellular signal transduction
GO:0042177 negative regulation of protein catabolic process
GO:0043278 response to morphine
GO:0043524 negative regulation of neuron apoptotic process
GO:0045087 innate immune response
GO:0046777 protein autophosphorylation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048265 response to pain
GO:0060384 innervation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0030054 cell junction
GO:0030425 dendrite
GO:0043005 neuron projection
GO:0048471 perinuclear region of cytoplasm
GO:0097060 synaptic membrane
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
EGFR1 pathway
Wnt pathway
Calmodulin induced events pathway
CaM pathway pathway
DAG and IP3 signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
Disinhibition of SNARE formation pathway
Response to elevated platelet cytosolic Ca2+ pathway
PLC-gamma1 signalling pathway
EGFR interacts with phospholipase C-gamma pathway
Signaling by EGFR pathway
G alpha (z) signalling events pathway
PLC beta mediated events pathway
Opioid Signalling pathway
PLCG1 events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
Phospholipase C-mediated cascade pathway
Signaling by FGFR pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Trafficking of GluR2-containing AMPA receptors pathway
Trafficking of AMPA receptors pathway
Signaling by FGFR in disease pathway
PCP/CE pathway pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
WNT5A-dependent internalization of FZD4 pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Neuronal System pathway
Signaling by GPCR pathway
Innate Immune System pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G-protein mediated events pathway
Immune System pathway
NGF signalling via TRKA from the plasma membrane pathway
Transmission across Chemical Synapses pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
Ca-dependent events pathway
Disease pathway
Hemostasis pathway
mTOR signaling pathway pathway
Vibrio cholerae infection pathway
VEGF signaling pathway pathway
Gap junction pathway
Non-small cell lung cancer pathway
Wnt signaling pathway pathway
ErbB signaling pathway pathway
MAPK signaling pathway pathway
Long-term potentiation pathway
Leukocyte transendothelial migration pathway
Tight junction pathway
Glioma pathway
Phosphatidylinositol signaling system pathway
Focal adhesion pathway
Long-term depression pathway
Natural killer cell mediated cytotoxicity pathway
Calcium signaling pathway pathway
Melanogenesis pathway
Fc gamma R-mediated phagocytosis pathway
Vascular smooth muscle contraction pathway
Pathways in cancer pathway
Aldosterone-regulated sodium reabsorption pathway
Gastric acid secretion pathway
Amoebiasis pathway
Pancreatic secretion pathway
Salivary secretion pathway
African trypanosomiasis pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
GPCR signaling pathway
Retinoic acid receptors-mediated signaling
UniProt Splice Variant
Entrez Gene 5582
UniGene Hs.631564
RefSeq NM_002739
OMIM 176980
HPRD 01502
EMBL AC008440
RNA Seq Atlas 5582