Version 5.4
| Mus musculus Gene: Prkcg | |||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-264090.7 | ||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||
| Gene Symbol | Prkcg | ||||||||||||||||||||||||||||||
| Gene Name | protein kinase C, gamma | ||||||||||||||||||||||||||||||
| Synonyms | Pkcc; PKCgamma; Prkcc | ||||||||||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000078816 | ||||||||||||||||||||||||||||||
| Encoded Proteins |
protein kinase C, gamma
protein kinase C, gamma
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| Protein Structure | |||||||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126583:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 7:3303532-3331094 | ||||||||||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||||||||||
| Band | A1 | ||||||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||
| REACTOME |
Innate Immune System pathway
WNT5A-dependent internalization of FZD4 pathway
Signaling by ERBB2 pathway
PLCG1 events in ERBB2 signaling pathway
GPCR downstream signaling pathway
Disease pathway
Hemostasis pathway
Signaling by Wnt pathway
Signaling by GPCR pathway
Ca-dependent events pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Signaling by FGFR in disease pathway
beta-catenin independent WNT signaling pathway
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
PLC-gamma1 signalling pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
EGFR interacts with phospholipase C-gamma pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
CaM pathway pathway
PCP/CE pathway pathway
Signaling by EGFR pathway
Disinhibition of SNARE formation pathway
G alpha (z) signalling events pathway
Phospholipase C-mediated cascade pathway
Signalling by NGF pathway
Signaling by PDGF pathway
Neuronal System pathway
Trafficking of GluR2-containing AMPA receptors pathway
DAG and IP3 signaling pathway
NGF signalling via TRKA from the plasma membrane pathway
Opioid Signalling pathway
Response to elevated platelet cytosolic Ca2+ pathway
Calmodulin induced events pathway
Signal Transduction pathway
Trafficking of AMPA receptors pathway
Transmission across Chemical Synapses pathway
Signaling by FGFR pathway
PLC beta mediated events pathway
G-protein mediated events pathway
Signaling by EGFR in Cancer pathway
DAP12 interactions pathway
DAP12 signaling pathway
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| KEGG |
Tight junction pathway
ErbB signaling pathway pathway
VEGF signaling pathway pathway
Calcium signaling pathway pathway
Melanogenesis pathway
Wnt signaling pathway pathway
Gap junction pathway
Natural killer cell mediated cytotoxicity pathway
Phosphatidylinositol signaling system pathway
MAPK signaling pathway pathway
Long-term potentiation pathway
Glioma pathway
mTOR signaling pathway pathway
Leukocyte transendothelial migration pathway
Long-term depression pathway
Non-small cell lung cancer pathway
Focal adhesion pathway
Fc gamma R-mediated phagocytosis pathway
Vascular smooth muscle contraction pathway
Pathways in cancer pathway
Aldosterone-regulated sodium reabsorption pathway
Amoebiasis pathway
Gastric acid secretion pathway
Salivary secretion pathway
Pancreatic secretion pathway
African trypanosomiasis pathway
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| INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
GPCR signaling pathway
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| PID NCI | |||||||||||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||
| NETPATH |
EGFR1 pathway
Wnt pathway
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| REACTOME |
Calmodulin induced events pathway
CaM pathway pathway
DAG and IP3 signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
Disinhibition of SNARE formation pathway
Response to elevated platelet cytosolic Ca2+ pathway
PLC-gamma1 signalling pathway
EGFR interacts with phospholipase C-gamma pathway
Signaling by EGFR pathway
G alpha (z) signalling events pathway
PLC beta mediated events pathway
Opioid Signalling pathway
PLCG1 events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
Phospholipase C-mediated cascade pathway
Signaling by FGFR pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Trafficking of GluR2-containing AMPA receptors pathway
Trafficking of AMPA receptors pathway
Signaling by FGFR in disease pathway
PCP/CE pathway pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
WNT5A-dependent internalization of FZD4 pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Neuronal System pathway
Signaling by GPCR pathway
Innate Immune System pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G-protein mediated events pathway
Immune System pathway
NGF signalling via TRKA from the plasma membrane pathway
Transmission across Chemical Synapses pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
Ca-dependent events pathway
Disease pathway
Hemostasis pathway
DAP12 interactions pathway
Signaling by Wnt pathway
Signaling by EGFR pathway
PLCG1 events in ERBB2 signaling pathway
Trafficking of GluR2-containing AMPA receptors pathway
Signaling by GPCR pathway
Signaling by PDGF pathway
Calmodulin induced events pathway
DAG and IP3 signaling pathway
WNT5A-dependent internalization of FZD4 pathway
PLC-gamma1 signalling pathway
Signaling by FGFR pathway
Hemostasis pathway
Immune System pathway
Transmission across Chemical Synapses pathway
EGFR interacts with phospholipase C-gamma pathway
Platelet activation, signaling and aggregation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Signaling by ERBB2 pathway
Signal Transduction pathway
Signaling by EGFR in Cancer pathway
G-protein mediated events pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
beta-catenin independent WNT signaling pathway
NGF signalling via TRKA from the plasma membrane pathway
PCP/CE pathway pathway
GPCR downstream signaling pathway
PLC beta mediated events pathway
Downstream signaling of activated FGFR pathway
Neuronal System pathway
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
Signalling by NGF pathway
Phospholipase C-mediated cascade pathway
Downstream signal transduction pathway
Opioid Signalling pathway
Innate Immune System pathway
Ca-dependent events pathway
CaM pathway pathway
Trafficking of AMPA receptors pathway
DAP12 signaling pathway
Disease pathway
Signaling by FGFR in disease pathway
Disinhibition of SNARE formation pathway
G alpha (z) signalling events pathway
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| KEGG |
mTOR signaling pathway pathway
Vibrio cholerae infection pathway
VEGF signaling pathway pathway
Gap junction pathway
Non-small cell lung cancer pathway
Wnt signaling pathway pathway
ErbB signaling pathway pathway
MAPK signaling pathway pathway
Long-term potentiation pathway
Leukocyte transendothelial migration pathway
Tight junction pathway
Glioma pathway
Phosphatidylinositol signaling system pathway
Focal adhesion pathway
Long-term depression pathway
Natural killer cell mediated cytotoxicity pathway
Calcium signaling pathway pathway
Melanogenesis pathway
Fc gamma R-mediated phagocytosis pathway
Vascular smooth muscle contraction pathway
Pathways in cancer pathway
Aldosterone-regulated sodium reabsorption pathway
Gastric acid secretion pathway
Amoebiasis pathway
Pancreatic secretion pathway
Salivary secretion pathway
African trypanosomiasis pathway
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| INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
GPCR signaling pathway
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| PID NCI |
Retinoic acid receptors-mediated signaling
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| Cross-References | |||||||||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||||||||
| TrEMBL | Q2NKI4 Q64493 | ||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||
| Entrez Gene | 18752 | ||||||||||||||||||||||||||||||
| UniGene | Mm.486870 Mm.7980 | ||||||||||||||||||||||||||||||
| RefSeq | NM_001291434 NM_011102 | ||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||
| CCDS | CCDS57470 | ||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||
| MGI ID | MGI:97597 | ||||||||||||||||||||||||||||||
| MGI Symbol | Prkcg | ||||||||||||||||||||||||||||||
| EMBL | AC217111 BC111807 X65720 | ||||||||||||||||||||||||||||||
| GenPept | AAI11808 CAA46636 | ||||||||||||||||||||||||||||||
| RNA Seq Atlas | 18752 | ||||||||||||||||||||||||||||||