Homo sapiens Gene: SCTR
Summary
InnateDB Gene IDBG-68042.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCTR
Gene Name secretin receptor
Synonyms SR;
Species Homo sapiens
Ensembl Gene ENSG00000080293
Encoded Proteins
secretin receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its receptor are suggested to be involved in pancreatic cancer and autism. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:119439843-119524494
Strand Reverse strand
Band q14.2
Transcripts
ENST00000019103 ENSP00000019103
ENST00000485440
ENST00000494326
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0015055 secretin receptor activity
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007586 digestion
GO:0007588 excretion
Cellular Component
GO:0005881 cytoplasmic microtubule
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Glucagon-type ligand receptors pathway
GPCR ligand binding pathway
Class B/2 (Secretin family receptors) pathway
KEGG
Neuroactive ligand-receptor interaction pathway
Pancreatic secretion pathway
Bile secretion pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P47872
TrEMBL
UniProt Splice Variant
Entrez Gene 6344
UniGene Hs.42091
RefSeq NM_002980
HUGO HGNC:10608
OMIM 182098
CCDS CCDS2127
HPRD 01628
IMGT
EMBL AB065660 AC013275 AY462218 CH471103 U13989 U20178 U28281
GenPept AAA64949 AAA87556 AAC50106 AAR25625 AAY14741 BAC05886 EAW95219
RNA Seq Atlas 6344